开发用于磁共振成像标记的锰掺杂硫化铅量子点。
Developing Mn-doped lead sulfide quantum dots for MRI labels.
作者信息
Turyanska Lyudmila, Moro Fabrizio, Patanè Amalia, Barr James, Köckenberger Walter, Taylor Alexander, Faas Henryk M, Fowler Maxine, Wigmore Peter, Trueman Rebecca C, Williams Huw E L, Thomas Neil R
机构信息
School of Physics and Astronomy, The University of Nottingham, NG72RD, UK.
出版信息
J Mater Chem B. 2016 Nov 14;4(42):6797-6802. doi: 10.1039/c6tb02574a. Epub 2016 Oct 17.
Magnetic interactions of Mn ions in lead sulfide (PbS) nanocrystals with protons in water are probed by NMR and MRI. A thin layer of capping molecules enables free solvent diffusion to the nanocrystal surface resulting in a decrease of proton relaxation times. Magnetic resonance imaging of neuronal cell pellets exposed to (PbMn)S at non-toxic concentrations demonstrates their prospects as MRI-labels.
通过核磁共振（NMR）和磁共振成像（MRI）探测了硫化铅（PbS）纳米晶体中锰离子与水中质子的磁相互作用。一层薄薄的封端分子使溶剂能够自由扩散到纳米晶体表面，从而导致质子弛豫时间缩短。对暴露于无毒浓度的（PbMn）S的神经元细胞沉淀进行磁共振成像，证明了它们作为MRI标记物的前景。
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