受细胞外基质启发的糖胺聚糖-胶原纤维组装。
Extracellular matrix-inspired assembly of glycosaminoglycan-collagen fibers.
作者信息
Carretero A, Soares da Costa D, Reis R L, Pashkuleva I
机构信息
3B's Research Group-Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, 4805-017 Taipas, Guimarães, Portugal.
出版信息
J Mater Chem B. 2017 May 7;5(17):3103-3106. doi: 10.1039/c7tb00704c. Epub 2017 Apr 24.
We report on the fabrication of fibers exclusively from the extracellular matrix components by interfacial complexation without using any crosslinking agent. The obtained fibers may have different biomedical applications as they are flexible, and cells adhere and remodel them. Moreover, their stability and thickness can be finely tuned by the sulfation degree of the used glycosaminoglycans.
我们报道了通过界面络合仅由细胞外基质成分制备纤维的方法，且未使用任何交联剂。所获得的纤维具有柔韧性，细胞能够附着并对其进行重塑，因此可能具有不同的生物医学应用。此外，它们的稳定性和厚度可以通过所用糖胺聚糖的硫酸化程度进行精细调节。
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