用于肿瘤靶向双模态SPECT/MR成像的多功能树枝状大分子基纳米平台的设计
The design of a multifunctional dendrimer-based nanoplatform for targeted dual mode SPECT/MR imaging of tumors.
作者信息
Luo Yu, Zhao Lingzhou, Li Xin, Yang Jia, Guo Lilei, Zhang Guixiang, Shen Mingwu, Zhao Jinhua, Shi Xiangyang
机构信息
State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, P. R. China.
出版信息
J Mater Chem B. 2016 Dec 7;4(45):7220-7225. doi: 10.1039/c6tb02190e. Epub 2016 Oct 12.
A multifunctional folic acid-targeted dendrimer-based nanoplatform was designed to have both Mn(ii) and Tc loaded via chelation. The formed nanoplatform displays good stability, cytocompatibility and hemocompatibility in a given concentration range, and can be used for targeted dual-mode single-photon emission computed tomography/magnetic resonance imaging of tumors.
设计了一种基于树枝状聚合物的多功能叶酸靶向纳米平台，通过螯合作用负载锰（II）和锝。所形成的纳米平台在给定浓度范围内表现出良好的稳定性、细胞相容性和血液相容性，可用于肿瘤的靶向双模态单光子发射计算机断层扫描/磁共振成像。
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