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基于树枝状大分子的正电子发射断层成像造影剂。

Dendrimer-based contrast agents for PET imaging.

机构信息

a Department of Nuclear Medicine , Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai , People's Republic of China.

b College of Chemistry, Chemical Engineering and Biotechnology , Donghua University , Shanghai , People's Republic of China.

出版信息

Drug Deliv. 2017;24(sup1):81-93. doi: 10.1080/10717544.2017.1399299.

DOI:10.1080/10717544.2017.1399299
PMID:29124984
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8812586/
Abstract

Positron emission tomography (PET) imaging offers physiological and biological information through the in vivo distribution of PET agents for disease diagnosis, therapy monitoring and prognosis evaluation. Due to the unique structural characteristics allowing for facile modification of targeting ligands and radionuclides, dendrimers can be served as a versatile scaffold to build up various PET imaging agents, and significant breakthroughs have been made in this field over the past decades. This review focuses on the recent advances in dendrimer-based contrast agents for PET imaging of cancer, cardiovascular and other diseases. In particular, radiolabeling strategies for different PET isotopes are described in detail. Several challenges involved in clinical translation of radiolabeled dendrimers are also discussed.

摘要

正电子发射断层扫描（PET）成像通过 PET 示踪剂在体内的分布提供生理和生物学信息，可用于疾病诊断、治疗监测和预后评估。由于独特的结构特征，树枝状聚合物允许靶向配体和放射性核素的轻松修饰，可以作为构建各种 PET 成像剂的多功能支架，在过去几十年中，该领域取得了重大突破。本综述重点介绍了基于树枝状聚合物的用于癌症、心血管和其他疾病的 PET 成像对比剂的最新进展。特别是，详细描述了用于不同 PET 同位素的放射性标记策略。还讨论了放射性标记树枝状聚合物临床转化中涉及的一些挑战。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3260/8812586/3288c6429f76/IDRD_A_1399299_F0005_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3260/8812586/283d2e6bd75f/IDRD_A_1399299_F0001_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3260/8812586/dfcec2200020/IDRD_A_1399299_F0002_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3260/8812586/f4a66e76c8d5/IDRD_A_1399299_F0003_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3260/8812586/7486e9aae58c/IDRD_A_1399299_F0004_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3260/8812586/3288c6429f76/IDRD_A_1399299_F0005_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3260/8812586/283d2e6bd75f/IDRD_A_1399299_F0001_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3260/8812586/dfcec2200020/IDRD_A_1399299_F0002_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3260/8812586/f4a66e76c8d5/IDRD_A_1399299_F0003_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3260/8812586/7486e9aae58c/IDRD_A_1399299_F0004_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3260/8812586/3288c6429f76/IDRD_A_1399299_F0005_B.jpg

相似文献

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Dendrimer-based contrast agents for PET imaging.

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引用本文的文献

[1]
Nanoradiopharmaceuticals: Design Principles, Radiolabeling Strategies, and Biomedicine Applications.

Pharmaceutics. 2025-7-14

[2]
Clinical Radiosynthesis and Translation of [F]OP-801: A Novel Radiotracer for Imaging Reactive Microglia and Macrophages.

ACS Chem Neurosci. 2023-7-5

[3]
Radiolabeling and Preliminary Evaluation of Tc-Labeled DNA Cube Nanoparticles as Potential Tracers for SPECT Imaging.

Int J Nanomedicine. 2021

[4]
SPECT/CT imaging of chemotherapy-induced tumor apoptosis using Tc-labeled dendrimer-entrapped gold nanoparticles.

Drug Deliv. 2018-11

[5]
Cu-Labeled multifunctional dendrimers for targeted tumor PET imaging.

Nanoscale. 2018-3-29

本文引用的文献

[1]
Improved biocompatibility of surface functionalized dendrimer-entrapped gold nanoparticles.

Soft Matter. 2006-12-13

[2]
The design of a multifunctional dendrimer-based nanoplatform for targeted dual mode SPECT/MR imaging of tumors.

J Mater Chem B. 2016-12-7

[3]
Radiolabelled Polymeric Materials for Imaging and Treatment of Cancer: Quo Vadis?

Adv Healthc Mater. 2017-2-20

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Dual nano-sized contrast agents in PET/MRI: a systematic review.

Contrast Media Mol Imaging. 2016-11

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Chem Rev. 2017-1-3

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Liposomes for PET and MR Imaging and for Dual Targeting (Magnetic Field/Glucose Moiety): Synthesis, Properties, and in Vivo Studies.

Mol Pharm. 2017-2-6

[7]
Robust surface coating for a fast, facile fluorine-18 labeling of iron oxide nanoparticles for PET/MR dual-modality imaging.

Nanoscale. 2016-12-1

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PET imaging approaches for inflammatory lung diseases: Current concepts and future directions.

Eur J Radiol. 2017-1

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Gold nanoparticles-based SPECT/CT imaging probe targeting for vulnerable atherosclerosis plaques.

Biomaterials. 2016-8-31

[10]
RGD-TPGS decorated theranostic liposomes for brain targeted delivery.

Colloids Surf B Biointerfaces. 2016-7-29

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