Wang Puxiu, Chu Wei, Zhuo Xuezhi, Zhang Yu, Gou Jingxin, Ren Tianyang, He Haibing, Yin Tian, Tang Xing
Department of Pharmaceutics, Shenyang Pharmaceutical University, Shenyang, 110016, China.
J Mater Chem B. 2017 Feb 28;5(8):1551-1565. doi: 10.1039/c6tb02158a. Epub 2017 Feb 2.
PLGA-PEG-PLGA (PPP) triblock copolymer is the most widely studied thermosensitive hydrogel owing to its non-toxic, biocompatible, biodegradable, and thermosensitive properties. PPP thermosensitive hydrogels are being investigated as in situ gels because, at a low temperature, PPP solutions with drugs can be injected at the target site, and converted into a gel without surgical procedures. To meet the requirements of different therapeutic applications, PPP hydrogels with different properties need to be synthesized. The adjustable properties include the sol-gel transition temperature, gel window width, retention time and drug release time. Furthermore, thermo- and pH-, thermo- and electro-, and thermo- and photo-dual sensitive hydrogels are needed for some special therapies. Thus, this review examines the methods of modification of PPP thermosensitive hydrogels used to obtain desired drug delivery systems with appropriate physicochemical and pharmaceutical properties.
聚乳酸-羟基乙酸共聚物-聚乙二醇-聚乳酸-羟基乙酸共聚物（PPP）三嵌段共聚物是研究最为广泛的热敏水凝胶，因其具有无毒、生物相容性好、可生物降解以及热敏性等特性。PPP热敏水凝胶正作为原位凝胶进行研究，因为在低温下，含药物的PPP溶液可在靶部位注射，并在无需外科手术的情况下转化为凝胶。为满足不同治疗应用的需求，需要合成具有不同特性的PPP水凝胶。可调节的特性包括溶胶-凝胶转变温度、凝胶窗口宽度、保留时间和药物释放时间。此外，一些特殊疗法需要热和pH、热和电以及热和光双敏感水凝胶。因此，本综述考察了用于获得具有适当物理化学和药学特性的理想药物递送系统的PPP热敏水凝胶的改性方法。
