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超薄石墨相氮化碳纳米片：一种与阿尔茨海默病相关的金属诱导淀粉样蛋白聚集的新型抑制剂。

An ultrathin graphitic carbon nitride nanosheet: a novel inhibitor of metal-induced amyloid aggregation associated with Alzheimer's disease.

作者信息

Li Meng, Guan Yijia, Ding Chao, Chen Zhaowei, Ren Jinsong, Qu Xiaogang

机构信息

Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China.

出版信息

J Mater Chem B. 2016 Jun 21;4(23):4072-4075. doi: 10.1039/c6tb01215a. Epub 2016 May 25.

DOI:10.1039/c6tb01215a
PMID:32264608
Abstract

Herein we report that a g-CN nanosheet can act as a nanochelator to inhibit Cu induced Aβ aggregation and disassemble the preformed Aβ-Cu aggregates.

摘要

在此我们报告，石墨相氮化碳纳米片可作为一种纳米螯合剂，抑制铜诱导的淀粉样β蛋白（Aβ）聚集，并拆解预先形成的Aβ-铜聚集体。

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