Department of Ophthalmology, Aier School of Ophthalmology, Central South University , Changsha, Hunan Province, China.
Department of Ophthalmology, Chengdu Aier Eye Hospital , Chengdu, Sichuan Province, China.
Curr Eye Res. 2020 Nov;45(11):1373-1379. doi: 10.1080/02713683.2020.1752387. Epub 2020 Apr 27.
: To analyze the clinical and regional distribution characteristics of obstructive meibomian gland dysfunction (OMGD) in China. : A total of 2900 patients (2900 eyes) diagnosed with OMGD were enrolled in this multicenter, cross-sectional, observational study. The Ocular Surface Disease Index (OSDI), tear film breakup time (FBUT), Schirmer test (SI), lipid layer thickness (LLT), OMGD grade, meibomian gland loss score (Meiboscore), meibum expressibility score (MES), meibum quality score (MQS), Lid margin abnormality score(LMS) and other tear film stability markers were evaluated. : The prevalence of dry eye in OMGD patients was 89%. There were gender differences among OMGD patients in the 30-39 and 50-59 years age groups ( < .05), and FBUT, Meiboscore, MES and MQS were significantly different among different OMGD grades ( < .05). There were significant differences in the detection indexes of OMGD patients in the six regions ( < .05), except LLT ( = .329). According to the Qinling-Huaihe River in China, OMGD patients were divided into the North Group (Shenyang and Beijing) and South Group (Wuhan, Changsha, Chongqing, and Chengdu). There was a significant difference in the detection indexes, except LLT ( = .600), between the two groups ( < .05). FBUT was significantly correlated with the OSDI (r = -0.131; < .000). Meiboscore and LLT were significantly correlated with the OMGD grade (r = 0.299 and r = 0.106; < .001). Age, LMS and MQS were significantly correlated with Meiboscore (r = 0.415, r = 0.256 and r = 0.328; < .001). : The prevalence of dry eye was high among OMGD patients. OMGD patients in different age groups may show different gender distributions. The symptoms of patients showed variation among subgroups with different OMGD grades and among different regions.
: 分析中国阻塞性睑板腺功能障碍（OMGD）的临床和地域分布特征。 : 本多中心、横断面、观察性研究纳入了 2900 名（2900 只眼）诊断为 OMGD 的患者。评估了眼表疾病指数（OSDI）、泪膜破裂时间（FBUT）、泪液分泌试验（SI）、脂质层厚度（LLT）、OMGD 分级、睑板腺缺失评分（Meiboscore）、睑脂排出评分（MES）、睑脂质量评分（MQS）、睑缘异常评分（LMS）和其他泪膜稳定性标志物。 : OMGD 患者的干眼症患病率为 89%。在 30-39 岁和 50-59 岁年龄组中，OMGD 患者的性别存在差异（ < 0.05），不同 OMGD 分级的 FBUT、Meiboscore、MES 和 MQS 差异均有统计学意义（ < 0.05）。六个地区的 OMGD 患者检测指标存在显著差异（ < 0.05），除 LLT（ =.329）外。根据中国的秦岭-淮河线，将 OMGD 患者分为北方组（沈阳和北京）和南方组（武汉、长沙、重庆和成都）。两组的检测指标存在显著差异，除 LLT（ =.600）外（ < 0.05）。FBUT 与 OSDI 呈显著负相关（r = -0.131； < 0.000）。Meiboscore 和 LLT 与 OMGD 分级呈显著正相关（r = 0.299 和 r = 0.106； < 0.001）。年龄、LMS 和 MQS 与 Meiboscore 呈显著正相关（r = 0.415、r = 0.256 和 r = 0.328； < 0.001）。 : OMGD 患者干眼症患病率较高。不同年龄组的 OMGD 患者可能表现出不同的性别分布。不同 OMGD 分级亚组和不同地区的患者症状存在差异。
