Reproductive Medical Center, Henan Provincial People's Hospital, People's Hospital of Henan University, Zhengzhou, People's Republic of China.
Reproductive Medical Center, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, People's Republic of China.
Gynecol Endocrinol. 2020 Nov;36(11):968-972. doi: 10.1080/09513590.2020.1742686. Epub 2020 Apr 8.
To investigate the effect of endometrial thickness on the clinical outcome of cleavage embryo HRT-FET on the day of embryo transfer and analyzed the threshold and optimal thickness interval corresponding to ideal clinical pregnancy rate by statistical method. A total of 5861 HRT-FET cycles with cleavage embryo transferred from January 2013 to December 2017 in the Reproductive Medicine Center of Henan Provincial People's Hospital were studied retrospectively．Fifth-order grouping of endometrial thickness (EMT) on embryo transfer day as a continuous variable by statistical software, they were divided into five subgroups: Q1 (EMT:4.0-7.9 mm), Q2 (EMT: 8.0-8.9 mm), Q3 (EMT: 9.0-9.5 mm), Q4 (EMT: 9. 6-10.9 mm), Q5 (EMT: 11.0-19.0 mm). After adjusting for confounding factors, the clinical pregnancy rate and live birth rate in other groups were higher than Group Q1 significantly ( < .05). The cutoff value of the endometrial thickness was 8.6 mm, When endometrial thickness was less than 8.6 mm, with each additional 1 mm of endometrial thickness, clinical pregnancy rate increased by 49% (OR = 1.49, 95%CI (1.35, 1.66), < .001), the live birth rate increased by 59% (OR= 1.59, 95%CI (1.42, 1.78), < .001), When the endometrial thickness was thicker than the threshold, clinical pregnancy rate (OR = 1.02, 95%CI (0.97, 1.07), = .398) and the live birth rate (OR = 1.00, 95%CI (0.96, 1.05), = .398) remained stable. In the cleavage embryo HRT-FET cycle, endometrial thickness is a curvilinear relationship with clinical outcome, the optimal endometrial thickness interval for ideal clinical outcome was 8.6-15mm.
探讨胚胎移植日子宫内膜厚度对卵裂期胚胎行激素替代治疗（HRT）冻融胚胎移植（FET）临床结局的影响，并采用统计学方法分析理想临床妊娠率对应的阈值及最佳厚度区间。
回顾性分析 2013 年 1 月至 2017 年 12 月在河南省人民医院生殖医学中心行卵裂期胚胎 HRT-FET 的 5861 个周期。采用统计软件将胚胎移植日子宫内膜厚度（EMT）五次方分组为连续变量，分为 5 个亚组：Q1（EMT：4.0-7.9mm）、Q2（EMT：8.0-8.9mm）、Q3（EMT：9.0-9.5mm）、Q4（EMT：9.6-10.9mm）、Q5（EMT：11.0-19.0mm）。校正混杂因素后，其他组的临床妊娠率和活产率均显著高于 Q1 组（<0.05）。子宫内膜厚度的截断值为 8.6mm，当子宫内膜厚度<8.6mm 时，子宫内膜厚度每增加 1mm，临床妊娠率增加 49%（OR=1.49，95%CI（1.35，1.66），<0.001），活产率增加 59%（OR=1.59，95%CI（1.42，1.78），<0.001）；当子宫内膜厚度超过阈值时，临床妊娠率（OR=1.02，95%CI（0.97，1.07），=0.398）和活产率（OR=1.00，95%CI（0.96，1.05），=0.398）保持稳定。在卵裂期胚胎 HRT-FET 周期中，子宫内膜厚度与临床结局呈曲线关系，理想临床结局的最佳子宫内膜厚度区间为 8.6-15mm。
