Center for Neuron and Disease, Frontier Institutes of Science and Technology, Xi'an Jiaotong University, Xi'an, China.
Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Mol Pain. 2020 Jan-Dec;16:1744806920917245. doi: 10.1177/1744806920917245.
Extracellular signal-regulated kinases are widely expressed protein kinases in neurons, which serve as important intracellular signaling molecules for central plasticity such as long-term potentiation. Recent studies demonstrate that there are two major forms of long-term potentiation in cortical areas related to pain: postsynaptic long-term potentiation and presynaptic long-term potentiation. In particular, presynaptic long-term potentiation in the anterior cingulate cortex has been shown to contribute to chronic pain-related anxiety. In this review, we briefly summarized the components and roles of extracellular signal-regulated kinases in neuronal signaling, especially in the presynaptic long-term potentiation of anterior cingulate cortex, and discuss the possible molecular mechanisms and functional implications in pain-related emotional disorders.
细胞外信号调节激酶是神经元中广泛表达的蛋白激酶，作为中枢可塑性的重要细胞内信号分子，如长时程增强。最近的研究表明，与疼痛相关的皮质区有两种主要形式的长时程增强：突触后长时程增强和突触前长时程增强。特别是，扣带前皮质的突触前长时程增强已被证明有助于慢性疼痛相关的焦虑。在这篇综述中，我们简要总结了细胞外信号调节激酶在神经元信号中的组成和作用，特别是在扣带前皮质的突触前长时程增强中的作用，并讨论了其在疼痛相关情绪障碍中的可能分子机制和功能意义。
