Yoshida Mina, Awano Nobuyasu, Inomata Minoru, Kuse Naoyuki, Tone Mari, Yoshimura Hanako, Jo Tatsunori, Takada Kohei, Kumasaka Toshio, Izumo Takehiro
Department of Respiratory Medicine, Japanese Red Cross Medical Center, 4-1-22 Hiroo, Shibuya-ku, Tokyo, 150-8935, Japan.
Department of Pathology, Japanese Red Cross Medical Center, 4-1-22 Hiroo, Shibuya-ku, Tokyo, 150-8935, Japan.
Respir Investig. 2020 Jul;58(4):295-299. doi: 10.1016/j.resinv.2020.02.005. Epub 2020 Apr 4.
Transbronchial lung biopsy is a non-invasive technique used primarily for the pathological diagnosis of lymphangioleiomyomatosis (LAM). However, some cases, particularly those with early-stage lung lesions, are difficult to diagnose because of the specimen size and presence of artifacts. Herein, we present two cases of LAM with relatively mild cystic changes in the lungs and slight impairment seen in pulmonary function tests. Both patients were diagnosed pathologically through transbronchial lung cryobiopsy. These cases indicate that transbronchial lung cryobiopsy is a useful tool for diagnosing early-stage pulmonary LAM owing to its appropriate specimen size for detecting LAM cells and few crush artifacts.
经支气管肺活检是一种主要用于淋巴管平滑肌瘤病（LAM）病理诊断的非侵入性技术。然而，一些病例，尤其是那些肺部病变处于早期阶段的病例，由于标本大小和伪像的存在而难以诊断。在此，我们报告两例肺部囊性改变相对较轻且肺功能测试显示轻度损害的LAM病例。两名患者均通过经支气管肺冷冻活检进行了病理诊断。这些病例表明，经支气管肺冷冻活检对于诊断早期肺部LAM是一种有用的工具，因为其标本大小适合检测LAM细胞且挤压伪像较少。
