Shirataki K, Chihara K, Shibata Y, Tamaki N, Matsumoto S, Fujita T
Department of Neurological Surgery, Kobe University School of Medicine, Japan.
Neurosurgery. 1988 Sep;23(3):395-8. doi: 10.1227/00006123-198809000-00024.
This report describes the clinical course of pituitary apoplexy induced by a single dose of bromocriptine in a 50-year-old woman with acromegaly. The patient suddenly complained of diminished vision and headache 2 hours after the oral administration of 2.5 mg of bromocriptine. Her visual symptoms and headache persisted for several days. The basal plasma GH concentration decreased from 76.2 ng/ml to 37.2 ng/ml the day after the attack of apoplexy and to 3.0 ng/ml on the 9th day. The authors assess the changes in endocrine findings related to pituitary apoplexy and also emphasize the necessity to view with caution any symptomatic change during bromocriptine therapy.
本报告描述了一名50岁肢端肥大症女性患者因单次服用溴隐亭诱发垂体卒中的临床过程。该患者口服2.5毫克溴隐亭2小时后突然出现视力减退和头痛。她的视觉症状和头痛持续了数天。垂体卒中发作后第二天，基础血浆生长激素浓度从76.2纳克/毫升降至37.2纳克/毫升，第9天降至3.0纳克/毫升。作者评估了与垂体卒中相关的内分泌检查结果变化，并强调在溴隐亭治疗期间对任何症状变化都要谨慎观察。
