Cao Shanshan, Zhang Jun, Wang Zhiqi, Pan Wen, Tian Yanghua, Hu Panpan, Wei Qiang, Wang Jingye, Shi Xiuli, Wang Kai
Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei, China.
Front Aging Neurosci. 2020 Mar 20;12:21. doi: 10.3389/fnagi.2020.00021. eCollection 2020.
Problems with attention are common in patients with cerebral small vessel disease (CSVD). The normal human brain exhibits functional and structural asymmetry. However, it is unknown whether there is lateralization of attention in patients with CSVD. This study aims to investigate attention separately in both cerebral hemispheres in patients with CSVD using the computer-based Lateralized Attention Network Test-Revised (LANT-R). The total number of subjects included was 58, which includes the CSVD ( = 35) and healthy control (HC, = 23) groups. All subjects completed the LANT-R paradigm and neuropsychological background tests. The results indicate that there is an left hemisphere (LH) lateralization in orienting network efficiency in the HC group. However, this lateralization was not apparent in the CSVD group. Furthermore, the difference between groups was significant (interaction = 0.02). In addition, the scores of subjects in the CSVD group are lower in several cognitive domains, including attention function, memory function, information processing speed, and executive function, compared with the controls. Patients with CSVD change in the lateralization of attention compared with the normal elderly. The decrease in attention in patients with CSVD might be caused by the reduced ability of selecting useful information in the LH.
注意力问题在脑小血管病（CSVD）患者中很常见。正常人类大脑表现出功能和结构上的不对称性。然而，CSVD患者的注意力是否存在偏侧化尚不清楚。本研究旨在使用基于计算机的修订版偏侧化注意力网络测试（LANT-R），分别对CSVD患者的两个大脑半球的注意力进行研究。纳入的受试者总数为58名，其中包括CSVD组（n = 35）和健康对照组（HC，n = 23）。所有受试者均完成了LANT-R范式和神经心理学背景测试。结果表明，HC组在定向网络效率方面存在左半球（LH）偏侧化。然而，这种偏侧化在CSVD组中并不明显。此外，两组之间的差异具有显著性（交互作用p = 0.02）。此外，与对照组相比，CSVD组受试者在包括注意力功能、记忆功能、信息处理速度和执行功能在内的几个认知领域得分较低。与正常老年人相比，CSVD患者的注意力偏侧化发生了变化。CSVD患者注意力下降可能是由于左半球选择有用信息的能力降低所致。
