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鞘内注射血清素在大鼠中产生的抗伤害感受作用可被一种选择性5-羟色胺3受体拮抗剂逆转。

Reversal of the antinociceptive effects of intrathecally administered serotonin in the rat by a selective 5-HT3 receptor antagonist.

作者信息

Glaum S R, Proudfit H K, Anderson E G

机构信息

Department of Pharmacology, University of Illinois, Chicago 60612.

出版信息

Neurosci Lett. 1988 Dec 19;95(1-3):313-7. doi: 10.1016/0304-3940(88)90677-5.

DOI:10.1016/0304-3940(88)90677-5
PMID:3226619
Abstract

The ability of the highly selective 5-HT3 receptor antagonist ICS 205-930 (3 alpha-tropanyl-1H-indole-3-carboxylic acid ester) to block the increase in tail flick (TFL) and hot plate latencies (HPL) produced by intrathecally (i.t.) administered serotonin (5-HT) was examined in pargyline pretreated rats. ICS 205-930 (0.1 microgram, i.t.) blocked the ability of 5-HT (200 micrograms) to increase TFL and HPL. Significant hyperalgesia, as measured by a decrease in TFL and HPL compared to saline controls, also resulted from either the coadministration of ICS 205-930 (10 micrograms) and 5-HT (200 micrograms) or from ICS 205-930 (100 micrograms) alone. These data suggest an important role for 5-HT3 receptors in modulating spinal nociceptive responses.

摘要

在帕吉林预处理的大鼠中，研究了高选择性5-羟色胺3（5-HT3）受体拮抗剂ICS 205-930（3α-托烷-1H-吲哚-3-羧酸酯）阻断鞘内注射5-羟色胺（5-HT）引起的甩尾潜伏期（TFL）和热板潜伏期（HPL）增加的能力。ICS 205-930（0.1微克，鞘内注射）阻断了5-HT（200微克）增加TFL和HPL的能力。与生理盐水对照组相比，TFL和HPL降低所测得的显著痛觉过敏，也可由ICS 205-930（10微克）和5-HT（200微克）共同给药或单独使用ICS 205-930（100微克）引起。这些数据表明5-HT3受体在调节脊髓伤害性反应中起重要作用。

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