Nothias F, Onteniente B, Roudier F, Peschanksi M
Unité de Recherches de Neurophysiologie Pharmacologique, INSERM U 161, Paris, France.
Neurosci Lett. 1988 Dec 19;95(1-3):59-63. doi: 10.1016/0304-3940(88)90632-5.
Whereas the anatomy and function of monoaminergic afferents to the spinal cord areas involved in somesthesia and pain have been widely studied, little is known about the monoaminergic innervation of the primary somatosensory thalamic relay nucleus. The present study demonstrates immunocytochemically at both the light and the electron microscopic levels the presence of noradrenergic and serotoninergic fibers in the ventrobasal complex of the rat thalamus (VB). Despite the presence of numerous immunoreactive varicosities, synaptic differentiation was not observed at the level of apposition of membranes between monoaminergic afferents and VB neuronal profiles. The hypothesis of a non-synaptic modulation of VB neuronal activity by monoaminergic afferents is discussed.
虽然对涉及躯体感觉和疼痛的脊髓区域的单胺能传入神经的解剖结构和功能已进行了广泛研究，但对初级躯体感觉丘脑中继核的单胺能神经支配却知之甚少。本研究通过免疫细胞化学方法，在光镜和电镜水平上均证实了大鼠丘脑腹侧基底复合体（VB）中存在去甲肾上腺素能和5-羟色胺能纤维。尽管存在大量免疫反应性膨体，但在单胺能传入神经与VB神经元轮廓之间的膜贴合水平未观察到突触分化。本文讨论了单胺能传入神经对VB神经元活动进行非突触调节的假说。
