常见药物中 N-亚硝基二甲胺的发现。
The Finding of N-Nitrosodimethylamine in Common Medicines.
机构信息
TPN Associates, LLC, Germantown, Maryland, USA.
Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts, USA.
出版信息
Oncologist. 2020 Jun;25(6):460-462. doi: 10.1634/theoncologist.2020-0142. Epub 2020 Apr 17.
Abstract
The FDA has ordered the withdrawal of all ranitidine products from the marketplace based on recent findings of increased and unacceptable levels of N‐nitrosodimethylamine (NDMA). This commentary reviews the sources and properties of NDMA, assesses the dangers it poses, and suggests measures to mitigate contamination.
摘要
美国食品药品监督管理局（FDA）基于最近发现的二甲亚硝胺（NDMA）水平升高且不可接受这一结果，下令将所有雷尼替丁产品撤出市场。本评论回顾了 NDMA 的来源和特性，评估了其构成的危险，并提出了减轻污染的措施。
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Oral intake of ranitidine increases urinary excretion of N-nitrosodimethylamine.口服雷尼替丁会增加 N-亚硝基二甲胺的尿排泄量。
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