Department of Chemistry, Bridge Institute, University of Southern California, Los Angeles, CA 90089, USA.
Department of Chemistry, Bridge Institute, University of Southern California, Los Angeles, CA 90089, USA; Department of Quantitative and Computational Biology, Bridge Institute, University of Southern California, Los Angeles, CA 90089, USA.
Structure. 2020 Apr 7;28(4):390-392. doi: 10.1016/j.str.2020.03.004.
In this issue of Structure, Asada et al. (2019) present angiotensin receptor ATR structure in complex with its main endogenous agonist, AngII peptide. Complementing the previous structural studies, the new complex structure sheds light on the ATR activation mechanism and opens new avenues for drug discovery targeting this enigmatic receptor.
在本期《结构》杂志中，Asada 等人（2019 年）展示了血管紧张素受体 ATR 与其主要内源性激动剂血管紧张素 II 肽的复合物结构。该新复合物结构补充了先前的结构研究，揭示了 ATR 激活机制，并为针对这个神秘受体的药物发现开辟了新途径。
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