Guangxi Key Laboratory of Tumor Immunology and Microenvironmental Regulation, Guilin Medical University, Guilin 541004, China.
Center for Promotion of International Education and Research, Faculty of Agriculture, Kyushu University, Fukuoka 819-0395, Japan.
Int J Mol Sci. 2020 Apr 6;21(7):2548. doi: 10.3390/ijms21072548.
Deubiquitinases (DUBs) are involved in various cellular functions. They deconjugate ubiquitin (UBQ) from ubiquitylated substrates to regulate their activity and stability. Studies on the roles of deubiquitylation have been conducted in various cancers to identify the carcinogenic roles of DUBs. In this review, we evaluate the biological roles of DUBs in cancer, including proliferation, cell cycle control, apoptosis, the DNA damage response, tumor suppression, oncogenesis, and metastasis. This review mainly focuses on the regulation of different downstream effectors and pathways via biochemical regulation and posttranslational modifications. We summarize the relationship between DUBs and human cancers and discuss the potential of DUBs as therapeutic targets for cancer treatment. This review also provides basic knowledge of DUBs in the development of cancers and highlights the importance of DUBs in cancer biology.
去泛素化酶（DUBs）参与多种细胞功能。它们从泛素化底物上去除泛素（UBQ），以调节其活性和稳定性。在各种癌症中进行去泛素化的研究，以确定 DUBs 的致癌作用。在这篇综述中，我们评估了 DUBs 在癌症中的生物学作用，包括增殖、细胞周期控制、细胞凋亡、DNA 损伤反应、肿瘤抑制、致癌和转移。这篇综述主要集中在通过生化调节和翻译后修饰来调节不同的下游效应物和途径。我们总结了 DUBs 与人类癌症之间的关系，并讨论了 DUBs 作为癌症治疗的治疗靶点的潜力。这篇综述还提供了 DUBs 在癌症发展中的基础知识，并强调了 DUBs 在癌症生物学中的重要性。
