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父母精神疾病与儿童和青少年受伤风险的关联:瑞典全国基于登记的队列研究。

Association between maternal and paternal mental illness and risk of injuries in children and adolescents: nationwide register based cohort study in Sweden.

机构信息

Department of Global Public Health, Karolinska Institutet, 17177 Stockholm, Sweden

Centre for Women's Mental Health, Division of Psychology and Mental Health, Faculty of Biology, Medicine and Health Sciences, University of Manchester, Manchester, UK.

出版信息

BMJ. 2020 Apr 8;369:m853. doi: 10.1136/bmj.m853.

Abstract

OBJECTIVE

To determine the association between parental mental illness and the risk of injuries among offspring.

DESIGN

Retrospective cohort study.

SETTING

Swedish population based registers.

PARTICIPANTS

1 542 000 children born in 1996-2011 linked to 893 334 mothers and 873 935 fathers.

EXPOSURES

Maternal or paternal mental illness (non-affective psychosis, affective psychosis, alcohol or drug misuse, mood disorders, anxiety and stress related disorders, eating disorders, personality disorders) identified through linkage to inpatient or outpatient healthcare registers.

MAIN OUTCOME MEASURES

Risk of injuries (transport injury, fall, burn, drowning and suffocation, poisoning, violence) at ages 0-1, 2-5, 6-9, 10-12, and 13-17 years, comparing children of parents with mental illness and children of parents without mental illness, calculated as the rate difference and rate ratio adjusted for confounders.

RESULTS

Children with parental mental illness contributed to 201 670.5 person years of follow-up, while children without parental mental illness contributed to 2 434 161.5 person years. Children of parents with mental illness had higher rates of injuries than children of parents without mental illness (for any injury at age 0-1, these children had an additional 2088 injuries per 100 000 person years; number of injuries for children with and without parental mental illness was 10 235 and 72 723, respectively). At age 0-1, the rate differences ranged from 18 additional transport injuries to 1716 additional fall injuries per 100 000 person years among children with parental mental illness compared with children without parental mental illness. A higher adjusted rate ratio for injuries was observed from birth through adolescence and the risk was highest during the first year of life (adjusted rate ratio at age 0-1 for the overall association between any parental mental illness that has been recorded in the registers and injuries 1.30, 95% confidence interval 1.26 to 1.33). Adjusted rate ratios at age 0-1 ranged from 1.28 (1.24 to 1.32) for fall injuries to 3.54 (2.28 to 5.48) for violence related injuries. Common and serious maternal and paternal mental illness was associated with increased risk of injuries in children, and estimates were slightly higher for common mental disorders.

CONCLUSIONS

Parental mental illness is associated with increased risk of injuries among offspring, particularly during the first years of the child's life. Efforts to increase access to parental support for parents with mental illness, and to recognise and treat perinatal mental morbidity in parents in secondary care might prevent child injury.

摘要

目的

确定父母精神疾病与子女受伤风险之间的关系。

设计

回顾性队列研究。

地点

瑞典基于人群的登记处。

参与者

1542000 名 1996-2011 年出生的儿童与 893334 名母亲和 873935 名父亲相关联。

暴露

通过与住院或门诊医疗记录的联系,确定母亲或父亲的精神疾病(非情感性精神病、情感性精神病、酒精或药物滥用、情绪障碍、焦虑和应激相关障碍、饮食障碍、人格障碍)。

主要结果测量

0-1、2-5、6-9、10-12 和 13-17 岁时的受伤风险(交通伤、跌倒、烧伤、溺水和窒息、中毒、暴力),比较有父母精神疾病的儿童和无父母精神疾病的儿童,通过调整混杂因素后的率差和率比进行计算。

结果

有父母精神疾病的儿童的随访时间为 201670.5 人年,而无父母精神疾病的儿童的随访时间为 2434161.5 人年。与无父母精神疾病的儿童相比,父母有精神疾病的儿童受伤率更高(0-1 岁时,每 10 万人年增加 2088 例伤害;有和无父母精神疾病的儿童的伤害人数分别为 10235 例和 72723 例)。在 0-1 岁时,与无父母精神疾病的儿童相比,父母有精神疾病的儿童的交通伤增加 18 例,跌倒伤增加 1716 例。从出生到青春期,受伤的调整后率比值均较高,生命的第一年风险最高(记录在登记册中的任何父母精神疾病与受伤之间的整体关联在 0-1 岁时的调整后率比值为 1.30,95%置信区间为 1.26 至 1.33)。0-1 岁时的调整后率比值范围从跌倒伤的 1.28(1.24 至 1.32)到与暴力相关的伤害的 3.54(2.28 至 5.48)。常见和严重的母亲和父亲的精神疾病与子女受伤风险增加有关,而常见精神障碍的估计值略高。

结论

父母的精神疾病与子女受伤风险增加有关,尤其是在孩子生命的头几年。努力增加父母对有精神疾病的父母的支持,并在二级保健中识别和治疗围产期精神疾病,可能有助于预防儿童受伤。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b437/7190076/48149b719616/neva052515.f1.jpg

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