霉酚酸酯联合类固醇治疗并发巨噬细胞活化综合征和狼疮活动的病例。
Case of using mycophenolate in combination with steroids for concurrent macrophage activation syndrome and lupus flare.
作者信息
Shah Kavina, Porter Andrew, Takhar Gagandeep, Reddy Venkat
机构信息
Rheumatology Department, West Middlesex University Hospital NHS Trust, London, UK
Rheumatology Department, West Middlesex University Hospital NHS Trust, London, UK.
出版信息
BMJ Case Rep. 2020 Apr 7;13(4):e231554. doi: 10.1136/bcr-2019-231554.
Abstract
This report highlights the importance of tailored treatment strategies in severe systemic lupus erythematosus (SLE) flares driving the life-threatening condition, macrophage activation syndrome (MAS). We report the case of a 42-year-old woman with active systemic lupus erythematosus (SLE) who was diagnosed with MAS within 3 days of onset of lethargy, rash, joint pain and significant cytopenias. This early diagnosis meant that her condition was managed with less intensive immunosuppression with only modest doses of steroids and mycophenolate mofetil.
摘要
本报告强调了针对严重系统性红斑狼疮（SLE）发作制定个性化治疗策略的重要性，这种发作会引发危及生命的巨噬细胞活化综合征（MAS）。我们报告了一例42岁活动性系统性红斑狼疮（SLE）女性患者的病例，该患者在出现嗜睡、皮疹、关节疼痛和明显血细胞减少症3天内被诊断为MAS。这一早期诊断意味着她的病情通过强度较低的免疫抑制治疗得到控制，仅使用了适量的类固醇和霉酚酸酯。
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