Department of Gynecologic Oncology, Azienda Ospedaliera Brotzu, Cagliari, Italy.
Medical Oncology Unit, "Nostra Signora di Bonaria" Hospital, San Gavino, Italy.
Sci Rep. 2020 Apr 8;10(1):6096. doi: 10.1038/s41598-020-63276-1.
The identification of prognostic and predictive markers is crucial for choosing the most appropriate management method for ovarian cancer patients. We aimed to assess the prognostic role of tumor-associated macrophage (TAM) polarization in advanced ovarian cancer patients. We carried out a prospective observational study that included 140 consecutive patients with advanced-stage high-grade serous ovarian cancer as well as patients with other histotypes of ovarian cancer and patients with ovarian metastasis from other sites between June 2013 and December 2018. Patients were enrolled at the time of laparoscopic surgery before receiving any antineoplastic treatment. We found that patients with high-grade serous papillary ovarian cancers had a prevalence of M1 TAMs, a higher M1/M2 ratio, and a longer overall survival (OS) and progression-free survival (PFS) than other patients. Regression analysis confirmed that there was a significant positive association between the M1/M2 ratio and an improved OS, PFS and platinum-free interval (PFI), both in the entire population and in patients stratified according to tumor type and initial surgery. Kaplan-Meier analysis was performed after the patients were divided into 2 groups according to the median M1/M2 ratio and revealed that patients with a high M1/M2 ratio had a higher OS, PFS and PFI than those with a low M1/M2 ratio. In conclusion, the prognostic and predictive role of TAM polarization in the tumor microenvironment could be of great clinical relevance and may allow the early identification of patients who are likely to respond to therapy. Further studies in a larger prospective sample are warranted.
肿瘤相关巨噬细胞（TAM）极化对晚期卵巢癌患者的预后和预测具有重要作用。我们旨在评估肿瘤相关巨噬细胞（TAM）极化对晚期卵巢癌患者的预后作用。我们进行了一项前瞻性观察性研究，纳入了 140 例连续的晚期高级别浆液性卵巢癌患者，以及其他组织学类型的卵巢癌患者和来自其他部位的卵巢转移癌患者，研究时间为 2013 年 6 月至 2018 年 12 月。在接受任何抗肿瘤治疗之前，患者在腹腔镜手术时入组。我们发现，高级别浆液性乳头状卵巢癌患者 M1 TAM 患病率较高，M1/M2 比值较高，总生存期（OS）和无进展生存期（PFS）较长。回归分析证实，M1/M2 比值与 OS、PFS 和无铂间期（PFI）的改善均呈显著正相关，无论是在整个人群中，还是在根据肿瘤类型和初始手术分层的患者中均如此。根据 M1/M2 比值中位数将患者分为 2 组后进行 Kaplan-Meier 分析，结果显示 M1/M2 比值较高的患者 OS、PFS 和 PFI 更高。总之，肿瘤微环境中 TAM 极化的预后和预测作用可能具有重要的临床意义，并可能有助于早期识别可能对治疗有反应的患者。需要进一步在更大的前瞻性样本中进行研究。
