Hojan-Jezierska Dorota, Chomiak Anna, Czopor Agata, Matthews-Kozanecka Maja, Majewska Anna, Urbaniak-Olejnik Marta, Matthews-Brzozowska Teresa
Department of Hearing Healthcare Profession, Chair of Biophysics, University of Medical Sciences, 60-780 Poznań, Poland.
Students Research Group of Department of Clinic of Maxillofacial Orthopaedics and Orthodontics, University of Medical Sciences, 60-780 Poznań, Poland.
Oncol Lett. 2020 May;19(5):3411-3416. doi: 10.3892/ol.2020.11447. Epub 2020 Mar 5.
Melanotic neuroectodermal tumor of infancy (MNTI) is a rare infantile tumor that originates from mesenchymal-neuroectodermal cells, the treatment of which uses platinum derivatives that can affect hearing loss. The present study evaluated the long-term effects of ototoxicity following chemotherapy with cisplatin, vincristine, cyclophosphamide, teniposide and adriamycin in a 10-year-old patient after surgical removal of a MNTI tumor at the age of 8 months. Audiometric tests (high-frequency tonal audiometry, speech audiometry, speech acoustics, tympanometry and absorbance measurements) were performed during a 10-year follow-up after receiving chemotherapy. Hearing disorders in the high-frequency range (6,000 to 16,000 Hz range) were demonstrated for both ears, indicating that these may be the long-term effects of chemotherapy with use of platinum compounds during the treatment of infants.
婴儿黑色素性神经外胚层肿瘤（MNTI）是一种罕见的婴儿肿瘤，起源于间充质 - 神经外胚层细胞，其治疗使用的铂类衍生物可能会导致听力损失。本研究评估了一名10岁患者在8个月大时手术切除MNTI肿瘤后，接受顺铂、长春新碱、环磷酰胺、替尼泊苷和阿霉素化疗后耳毒性的长期影响。在接受化疗后的10年随访期间进行了听力测试（高频纯音听力测定、言语听力测定、言语声学、鼓室图和吸收率测量）。双耳均出现高频范围（6000至16000赫兹范围）的听力障碍，表明这些可能是婴儿期治疗期间使用铂类化合物化疗的长期影响。
