Sen Parveen, Sudharshan Sridharan, Banerjee Aniruddha, Dhami Abhinav
Department of Retina, Shri Bhagwan Mahavir Vitreoretinal Services - Sankara Nethralaya, Chennai, India.
Medical Research Foundation, Chennai, India.
GMS Ophthalmol Cases. 2020 Feb 27;10:Doc08. doi: 10.3205/oc000135. eCollection 2020.
Efavirenz (EFV), a non-nucleoside reverse transcriptase inhibitor, is commonly used to treat HIV-infected individuals. We report a case of painless, progressive and bilateral blurring of vision in an HIV-positive 54-year-old lady within months of treatment with anti-retro viral therapy including Efavirenz. On presentation, her visual acuity was 6/18; N24 and 6/9; N10 in both eyes with mottling of the retinal pigment epithelial at the macula with corresponding scotomas on HVF 30-2 and loss of ellipsoid layer on spectral domain optical coherence topography (OCT). Though full field ERG was normal, multifocal ERG revealed reduced foveal and parafoveal amplitudes. Our case emphasizes the need of periodic ocular examination of these patients on long-term EFV.
依非韦伦（EFV）是一种非核苷类逆转录酶抑制剂，常用于治疗HIV感染患者。我们报告了一例54岁HIV阳性女性患者，在接受包括依非韦伦在内的抗逆转录病毒治疗数月内出现无痛性、进行性双侧视力模糊。就诊时，她的视力为右眼6/18；N24，左眼6/9；N10，双眼黄斑区视网膜色素上皮出现斑驳，在HVF 30-2上有相应的暗点，光谱域光学相干断层扫描（OCT）显示椭圆体层缺失。尽管全视野视网膜电图正常，但多焦视网膜电图显示中央凹和中央凹旁振幅降低。我们的病例强调了对长期使用依非韦伦的这些患者进行定期眼部检查的必要性。
