Gratton A, Hoffer B J, Gerhardt G A, Wise R A
Douglas Hospital Research Center, McGill University, Verdun, Quebec, Canada.
Pharmacol Biochem Behav. 1988 Aug;30(4):1077-9. doi: 10.1016/0091-3057(88)90142-6.
Contraversive circling induced by unilateral infusions of morphine (7.5 nanomoles or 5 micrograms) into the ventral tegmental area was studied under conditions of dopamine uptake inhibition. Dopamine uptake blockade with either nomifensine (2.5 mg/kg) or GBR 13069 (2.0 mg/kg) resulted in a 3-fold increase in the rate of circling. Naloxone (1.5 mg/kg) attenuated but did not completely block the potentiated circling. These data are consistent with the hypothesis that morphine causes contraversive circling through local activation or disinhibition of dopaminergic cell firing.
在多巴胺摄取抑制的条件下，研究了向腹侧被盖区单侧注射吗啡（7.5纳摩尔或5微克）所诱导的反向旋转。用诺米芬辛（2.5毫克/千克）或GBR 13069（2.0毫克/千克）阻断多巴胺摄取，导致旋转速率增加了3倍。纳洛酮（1.5毫克/千克）减弱但并未完全阻断增强的旋转。这些数据与吗啡通过局部激活或解除多巴胺能细胞放电的抑制来引起反向旋转的假设一致。
