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成骨作用:如何刺激成骨?

Osteogenesis: how can it be stimulated?

机构信息

Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy.

Maxillofacial and Dental Unit, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Via Commenda 10, 20122 Milan, Italy.

出版信息

J Biol Regul Homeost Agents. 2020 Jan-Feb;34(1 Suppl. 2):19-24. DENTAL SUPPLEMENT.

Abstract

Biophysical therapy can be performed using inductive, capacitive, mechanic or implanted devices. The mechanism of action of physical stimuli is at a membrane level where the activation of calcium channels determines the enhancement of cell proliferation and the production of growth factors. Biophysical therapy should be performed using devices and modalities described in the literature. The biophysical stimulation of osteogenesis is effective in the enhancement of the biology of fracture healing in presence of a correct orthopedic treatment in terms of good alignment and stabilization at the fracture site. The choice of which method must be used depends on the segment of bone that has to be treated, the type of fracture and if it is possible to apply the device on the skin. The presence of internal or external fixation devices is not a contraindication.

摘要

物理治疗可以通过感应、电容、机械或植入设备进行。物理刺激的作用机制发生在细胞膜水平,其中钙通道的激活决定了细胞增殖和生长因子产生的增强。物理治疗应使用文献中描述的设备和方式进行。在正确的骨科治疗(即骨折部位良好的对线和稳定)的情况下,骨生成的生物物理刺激可有效增强骨折愈合的生物学特性。选择使用哪种方法取决于要治疗的骨骼部位、骨折类型以及是否可以将设备应用于皮肤。内部或外部固定装置的存在不是禁忌症。

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