Department of Infectious Diseases, St Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.
Department of Infectious Diseases, St Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.
Cell Host Microbe. 2020 Apr 8;27(4):489-490. doi: 10.1016/j.chom.2020.03.013.
Horizontal gene transfer (HGT) facilitates spead of antibiotic resistance elements. In this issue of Cell Host & Microbe, Domenech et al. discover that compounds disrupting proton motive force block natural competence (COM) and interrupt intraspecies HGT and exchange of antibiotic resistance. Such strategies might minimize clinical spread of antibiotic resistance.
水平基因转移（HGT）促进了抗生素耐药元件的传播。在本期《Cell Host & Microbe》杂志中，Domenech 等人发现，破坏质子动力势的化合物可以阻断自然感受态（COM），并中断种内 HGT 和抗生素耐药性的交换。此类策略可能最大限度地减少抗生素耐药性在临床上的传播。
