HIV-1 潜伏库的生物学特性及其对治愈策略的影响。
The Biology of the HIV-1 Latent Reservoir and Implications for Cure Strategies.
机构信息
Chan Zuckerberg Biohub, San Francisco, CA; Department of Medicine, University of California, San Francisco, CA.
Centre de recherche du CHUM and Department of Microbiology, Infectiology and Immunology, Université de Montréal, Montreal, QC, Canada.
出版信息
Cell Host Microbe. 2020 Apr 8;27(4):519-530. doi: 10.1016/j.chom.2020.03.014.
Abstract
Antiretroviral therapy (ART) inhibits HIV replication but is not curative. During ART, the integrated HIV genome persists indefinitely within CD4 T cells and perhaps other cells. Here, we describe the mechanisms thought to contribute to its persistence during treatment and highlight findings from numerous recent studies describing the importance of cell proliferation in that process. Continued progress elucidating the biology will enhance our ability to develop effective curative interventions.
摘要
抗逆转录病毒疗法（ART）可抑制 HIV 复制，但无法治愈。在 ART 期间，整合的 HIV 基因组会无限期地存在于 CD4 T 细胞及其他细胞中。本文描述了人们认为有助于解释治疗期间其持续存在的机制，并重点介绍了最近众多描述细胞增殖在这一过程中重要性的研究结果。阐明生物学机制的持续进展将提高我们开发有效治疗性干预措施的能力。
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本文引用的文献
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