College of Health Science, Woldia University, Woldia, Ethiopia.
College of Health Science, Axum University, Axum, Ethiopia.
BMC Pregnancy Childbirth. 2020 Apr 9;20(1):205. doi: 10.1186/s12884-020-02909-9.
Hypertensive disorders of pregnancy are among the most common causes of perinatal death. The disorders are highly linked to multiple factors that make prediction and prevention challenging. Early diagnosis and proper management play a crucial role in the wellbeing and life of the women and her baby. In this study, we aimed to assess the association between different management options of preeclampsia and perinatal death at a public hospital in Ethiopia.
A document review was conducted on 241 preeclamptic patients' medical files who have been admitted and delivered in Woldia General Hospital from 2011 to 2016. The study was conducted from August 8 - September 10, 2017 in the aforementioned public hospital in Woldia town, Ethiopia. Associations were tested using Pearson chi squared test and binary logistic regression with a p-value < 0.05 considered significant.
In this study, nearly 20 every 100 neonates from preeclamptic women has been died and the figure was higher (76.59% Vs 23.4%) among neonates from severe preeclamptic women than mild preeclamptic women (p = 0.01). More than two thirds of the patients (69.3%) received magnesium sulfate to prevent convulsion. Perinatal death among women with diastolic blood pressures greater than 110 mmHg at admission was nearly 3 times (Adjusted Odds Ratio (AOR) = 2.824; 95% Confidence Interval (CI) (1.154-6.038)) higher compared to women with diastolic blood pressures below 110 mmHg.
In the 5-year period, the magnitude of perinatal death among inpatient preeclamptic women was remarkably high and of which stillbirths exceeded pre-discharge early neonatal death. Utilization of magnesium sulfate tended to increase across years. Maternal diastolic blood pressure at admission was significantly associated with perinatal death.
妊娠高血压疾病是围产儿死亡的最常见原因之一。这些疾病与多种因素高度相关，使得预测和预防具有挑战性。早期诊断和适当的管理对妇女及其婴儿的健康和生命起着至关重要的作用。本研究旨在评估埃塞俄比亚一家公立医院不同的子痫前期管理方案与围产儿死亡之间的关联。
对 2011 年至 2016 年期间在沃尔迪亚综合医院住院分娩的 241 例子痫前期患者的病历进行了文献回顾。这项研究于 2017 年 8 月 8 日至 9 月 10 日在沃尔迪亚镇的上述公立医院进行。使用 Pearson 卡方检验和二项逻辑回归检验进行关联检验，p 值<0.05 认为具有统计学意义。
在这项研究中，每 100 例子痫前期妇女的新生儿中就有近 20 例死亡，而重度子痫前期妇女的新生儿中这一比例（76.59%）高于轻度子痫前期妇女（23.4%）（p=0.01）。超过三分之二的患者（69.3%）接受硫酸镁预防抽搐。入院时舒张压大于 110mmHg 的产妇围产儿死亡的风险几乎是舒张压低于 110mmHg 的产妇的 3 倍（调整后的优势比（AOR）=2.824；95%置信区间（CI）（1.154-6.038））。
在 5 年期间，住院子痫前期妇女的围产儿死亡比例相当高，其中死产超过了出院前早期新生儿死亡。硫酸镁的使用呈逐年增加趋势。入院时的产妇舒张压与围产儿死亡显著相关。
