Bouwens L
Laboratory for Cell Biology and Histology, Free University of Brussels, Belgium.
Scand J Gastroenterol Suppl. 1988;151:46-51. doi: 10.3109/00365528809095913.
The four types of non-parenchymal sinusoid lining cells can be identified in situ and can be isolated for in vitro studies: the fenestrated endothelial cells, the phagocytic Kupffer cells, the fibroblast-like fat-storing cells, and the 'natural killer' pit cells. In situ the last three sinusoidal cell types can be seen to proliferate and increase in number in experimental models of liver pathology, such as inflammations and fibrosis. The understanding of the population dynamics of these cells--their mitotic activity, turnover time, and migration--may therefore have clinical applications. In the present article our data concerning the proliferation kinetics of Kupffer and pit cells in rat liver are reviewed.
四种非实质窦状隙衬里细胞可在原位识别，并可分离出来用于体外研究：有窗孔的内皮细胞、吞噬性枯否细胞、成纤维细胞样贮脂细胞和“自然杀伤”性陷窝细胞。在原位，后三种窦状隙细胞类型在肝脏病理学实验模型（如炎症和纤维化）中可见增殖且数量增加。因此，了解这些细胞的群体动态——它们的有丝分裂活性、更新时间和迁移——可能具有临床应用价值。在本文中，我们回顾了关于大鼠肝脏中枯否细胞和陷窝细胞增殖动力学的数据。
