Kedinger M, Simon-Assmann P, Bouziges F, Haffen K
INSERM Unit 61, Strasbourg, France.
Scand J Gastroenterol Suppl. 1988;151:62-9. doi: 10.3109/00365528809095915.
The complex morphogenetic events and the concomitant structural and functional differentiation of intestinal progenitor cells are dependent on tissue interactions. Several experimental models of hetero-species or -topic recombinants between epithelial and mesenchymal anlagen are described. They enabled us to elucidate the respective roles of these tissue components in morphogenesis, epithelial differentiation, and hormone-elicited responses. Among the mechanisms of tissue interactions, the possible mediation of permissive and instructive information via the extracellular matrix is postulated. Arguments in favor of this are provided by the observation of compositional changes in matrix molecules during intestinal development and differentiation. On the other hand, in vitro experimental data emphasize the role of actual contacts between epithelial and mesenchymal cell populations and the importance of the mesenchyme for basement membrane formation.
肠道祖细胞复杂的形态发生事件以及随之而来的结构和功能分化依赖于组织间的相互作用。本文描述了上皮和间充质原基之间异种或异位重组的几种实验模型。这些模型使我们能够阐明这些组织成分在形态发生、上皮分化和激素引发反应中的各自作用。在组织相互作用的机制中，推测细胞外基质可能介导许可性和指导性信息。支持这一观点的证据来自于对肠道发育和分化过程中基质分子组成变化的观察。另一方面，体外实验数据强调了上皮和间充质细胞群之间实际接触的作用以及间充质对基底膜形成的重要性。
