Deschner E E
Laboratory of Digestive Tract Carcinogenesis, Memorial Sloan-Kettering Cancer Center, New York, New York 10021.
Scand J Gastroenterol Suppl. 1988;151:94-7. doi: 10.3109/00365528809095919.
The preneoplastic events occurring in the mucosa of patients at risk of developing colonic cancer are described and correlate well with the histogenesis of an adenoma. Confirmatory evidence from experimental carcinogenesis systems is provided. Among individuals at 50% risk of colon cancer, proliferative abnormalities relating to the distribution of S-phase cells are present. Aging, whether among the high-risk or the unaffected control population, appears to bring about enhancement of the percentage of DNA-synthesizing cells in the crypts, indicating a similar response of colonic epithelial cells to environmental conditions over time. The combination of an already existing defect in cell proliferation among those at high risk of familial colon cancer along with an elevated rate of cell renewal increases the probability that a neoplasm will arise in this population.
描述了有患结肠癌风险的患者黏膜中发生的癌前事件，这些事件与腺瘤的组织发生密切相关。还提供了来自实验致癌系统的确证证据。在患结肠癌风险为50%的个体中，存在与S期细胞分布相关的增殖异常。无论在高危人群还是未受影响的对照人群中，衰老似乎都会导致隐窝中DNA合成细胞的百分比增加，这表明随着时间的推移，结肠上皮细胞对环境条件有类似的反应。在家族性结肠癌高危人群中，细胞增殖本已存在的缺陷与细胞更新率升高相结合，增加了该人群发生肿瘤的可能性。
