瘦素水平与肥胖青少年的亚临床心脏功能障碍有关。
Leptin Levels are Associated with Subclinical Cardiac Dysfunction in Obese Adolescents.
作者信息
Imerbtham Thamonwan, Thitiwuthikiat Piyanuch, Jongjitwimol Jirapas, Nuamchit Teonchit, Yingchoncharoen Teerapat, Siriwittayawan Duangduan
机构信息
Department of Cardio-Thoracic Technology, Faculty of Allied Health Sciences, Naresuan University, Phitsanulok, Thailand.
Department of Medical Technology, Faculty of Allied Health Sciences, Naresuan University, Phitsanulok, Thailand.
出版信息
Diabetes Metab Syndr Obes. 2020 Mar 27;13:925-933. doi: 10.2147/DMSO.S245048. eCollection 2020.
PURPOSE
The purposes of this study were to use speckle tracking echocardiography to confirm the influence of obesity on cardiac functions and to assess their relationships with leptin and uric acid levels in obese adolescents.
METHODS
Eighty-one participants aged 16-19 years were recruited and classified as either non-obese (n = 30) or obese (n = 51). Global longitudinal strain (GLS), leptin and uric acid levels for each group were assessed and compared. The data from obese participants were then compared based on their leptin levels and analyzed for correlation using regression analysis.
RESULTS
The obese group had significantly lower absolute GLS compared to the non-obese group (19.10 ± 0.30 versus 21.10 ± 0.30%, < 0.001). In obese group, subclinical cardiac dysfunction was worse in the hyperleptinemic group than that of the normoleptinemic group ( = 0.03). Multivariate regression analysis showed that leptin and triglyceride levels were negatively associated with absolute GLS. Leptin could predict the absolute GLS with β = -0.35 ( = 0.02).
CONCLUSION
Subclinical left ventricular systolic dysfunction was found in obese adolescents, while GLS was worse in the hyperleptinemic subjects. Leptin, but not uric acid, levels were associated with a worsening of GLS.
目的
本研究旨在运用斑点追踪超声心动图来证实肥胖对心脏功能的影响，并评估肥胖青少年中其与瘦素和尿酸水平的关系。
方法
招募了81名年龄在16 - 19岁的参与者，分为非肥胖组（n = 30）和肥胖组（n = 51）。对每组的整体纵向应变（GLS）、瘦素和尿酸水平进行评估并比较。然后根据肥胖参与者的瘦素水平对数据进行比较，并使用回归分析来分析相关性。
结果
肥胖组的绝对GLS显著低于非肥胖组（19.10 ± 0.30对21.10 ± 0.30%，< 0.001）。在肥胖组中，高瘦素血症组的亚临床心脏功能障碍比正常瘦素血症组更严重（ = 0.03）。多因素回归分析显示，瘦素和甘油三酯水平与绝对GLS呈负相关。瘦素可以预测绝对GLS，β = -0.35（ = 0.02）。
结论
在肥胖青少年中发现了亚临床左心室收缩功能障碍，而高瘦素血症受试者的GLS更差。与GLS恶化相关的是瘦素水平，而非尿酸水平。
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