Suppr超能文献

.个体基因型中的转座元件

Transposable elements in individual genotypes of .

作者信息

Signor Sarah

机构信息

Department of Biological Sciences North Dakota State University Fargo ND USA.

出版信息

Ecol Evol. 2020 Mar 13;10(7):3402-3412. doi: 10.1002/ece3.6134. eCollection 2020 Apr.

Abstract

Transposable elements are abundant, dynamic components of the genome that affect organismal phenotypes and fitness. In , they have increased in abundance as the species spread out of Africa, and different populations differ in their transposable element content. However, very little is currently known about how transposable elements differ between individual genotypes, and how that relates to the population dynamics of transposable elements overall. The sister species of , , has also recently become cosmopolitan, and panels of inbred genotypes exist from cosmopolitan and African flies. Therefore, we can determine whether the differences in colonizing populations are repeated in , what the dynamics of transposable elements are in individual genotypes, and how that compares to wild flies. After estimating copy number in cosmopolitan and African , I find that transposable element load is higher in flies from cosmopolitan populations. In addition, transposable element load varies considerably between populations, between genotypes, but not overall between wild and inbred lines. Certain genotypes either contain active transposable elements or are more permissive of transposition and accumulate copies of particular transposable elements. Overall, it is important to quantify genotype-specific transposable element dynamics as well as population averages to understand the dynamics of transposable element accumulation over time.

摘要

转座元件是基因组中丰富且动态的组成部分,会影响生物体的表型和适应性。在[物种名称]中,随着该物种从非洲扩散开来,它们的丰度有所增加,并且不同种群的转座元件含量也有所不同。然而,目前对于转座元件在个体基因型之间如何不同,以及这与转座元件总体的种群动态有何关系,了解得非常少。[物种名称]的姊妹物种[另一物种名称]最近也遍布全球,并且存在来自全球和非洲果蝇的近交基因型面板。因此,我们可以确定在[另一物种名称]中,定殖种群中的差异是否会重复出现,转座元件在个体基因型中的动态是怎样的,以及与野生果蝇相比情况如何。在估计了全球和非洲[物种名称]的拷贝数后,我发现来自全球种群的果蝇中转座元件负载更高。此外,转座元件负载在种群之间、基因型之间差异很大,但在野生型和近交系之间总体上没有差异。某些基因型要么含有活跃的转座元件,要么对转座更宽容,从而积累特定转座元件的拷贝。总体而言,量化特定基因型的转座元件动态以及种群平均值对于理解转座元件随时间积累的动态很重要。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验