Department of Ophthalmology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Francis I. Proctor Foundation, University of California, San Francisco, California, USA.
Ocul Immunol Inflamm. 2021 Aug 18;29(6):1145-1150. doi: 10.1080/09273948.2020.1728344. Epub 2020 Apr 10.
: To determine the incidence of contralateral eye involvement and retinal detachment in HIV-infected patients with cytomegalovirus retinitis treated with repeated intravitreous ganciclovir.: In a prospective cohort study in Northern Thailand, HIV-infected patients with cytomegalovirus retinitis were treated with antiretroviral therapy and intravitreous ganciclovir injections and followed for 3 months for contralateral cytomegalovirus retinitis and retinal detachment.: Of 49 participants with unilateral cytomegalovirus retinitis at enrollment, 7 developed contralateral eye involvement (4.8/100 person-months, 95% CI 1.9-9.8). Of 105 eyes without a retinal detachment at enrollment, 6 developed a retinal detachment (2.0/100 eye-months, 95% CI 0.7-4.3). Baseline clinical factors were not associated with the development of either outcome.: Eyes treated with intravitreous ganciclovir experienced retinal detachment at a rate similar to other populations treated with systemic antivirals. The risk of contralateral eye involvement was relatively high during the first 3 months after initial diagnosis despite the institution of antiretroviral therapy.
: 评估接受重复玻璃体内更昔洛韦治疗的巨细胞病毒视网膜炎的 HIV 感染者中对侧眼受累和视网膜脱离的发生率。
: 在泰国北部进行的一项前瞻性队列研究中，对患有巨细胞病毒视网膜炎的 HIV 感染者进行抗逆转录病毒治疗和玻璃体内更昔洛韦注射治疗，并在 3 个月内对其对侧巨细胞病毒视网膜炎和视网膜脱离进行随访。
: 在入组时患有单侧巨细胞病毒视网膜炎的 49 名参与者中，有 7 名出现对侧眼受累（4.8/100 人月，95%CI1.9-9.8）。在入组时没有视网膜脱离的 105 只眼中，有 6 只出现视网膜脱离（2.0/100 眼月，95%CI0.7-4.3）。基线临床因素与两种结局的发生均无关联。
: 接受玻璃体内更昔洛韦治疗的眼睛发生视网膜脱离的比率与接受全身抗病毒药物治疗的其他人群相似。尽管开始进行抗逆转录病毒治疗，但在初始诊断后的头 3 个月内，对侧眼受累的风险仍然相对较高。
