Kang Yiwei, Yu Xujiang, Fan Xinyang, Zhao Shengzhe, Tu Chunlai, Yan Zhiqiang, Wang Ruibin, Li Wanwan, Qiu Huibin
School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, State Key Laboratory of Metal Matrix Composite, Shanghai Jiao Tong University, Shanghai 200240, China.
Instrumental Analysis Center, Shanghai Jiao Tong University, Shanghai 200240, China.
ACS Nano. 2020 Apr 28;14(4):4336-4351. doi: 10.1021/acsnano.9b09858. Epub 2020 Apr 16.
The abundant species of functional nanomaterials have attracted tremendous interests as components to construct multifunctional composites for cancer theranostics. However, their distinct chemical properties substantially require a specific strategy to integrate them in harmony. Here, we report the preparation of a distinctive multifunctional composite by encapsulating small-sized semiconducting copper bismuth sulfide (CBS) nanoparticles and rare-earth down-conversion (DC) nanoparticles in larger-sized zeolitic imidazolate framework-8 (ZIF8) nanoparticles, followed by loading an anticancer drug, doxorubicin (DOX). Such composites can be used for tetramodal imaging, including traditional computed tomography and magnetic resonance imaging and, recently, for photoacoustic imaging and fluorescence imaging. With a pH-responsive release of the encapsulated components, synergistic radio-chemotherapy with a high (87.6%) tumor inhibition efficiency is achieved at moderate doses of the CBS&DC-ZIF8@DOX composite with X-ray irradiation. This promising strategy highlights the extending capacity of zeolitic imidazolate frameworks to encapsulate multiple distinct components for enhanced cancer imaging and therapy.
功能纳米材料种类丰富，作为构建用于癌症诊疗的多功能复合材料的组分，已引起了人们极大的兴趣。然而，它们独特的化学性质在很大程度上需要一种特定的策略来使其和谐整合。在此，我们报道了一种独特的多功能复合材料的制备方法，即将小尺寸的半导体硫化铜铋（CBS）纳米颗粒和稀土下转换（DC）纳米颗粒封装在大尺寸的沸石咪唑酯骨架-8（ZIF8）纳米颗粒中，随后负载抗癌药物阿霉素（DOX）。这种复合材料可用于四模态成像，包括传统的计算机断层扫描和磁共振成像，以及最近的光声成像和荧光成像。随着封装成分的pH响应释放，在中等剂量的CBS&DC-ZIF8@DOX复合材料进行X射线照射时，可实现协同放化疗，肿瘤抑制效率高达87.6%。这一有前景的策略突出了沸石咪唑酯骨架封装多种不同成分以增强癌症成像和治疗的扩展能力。
