Concepcion Nathan David P, Romberg Erin K, Phillips Grace S, Lee Edward Y, Laya Bernard F
Section of Pediatric Radiology, Institute of Radiology, St. Luke's Medical Center-Global City, Rizal Drive cor. 32nd Street and 5th Avenue, Taguig City 1634, Philippines; St. Luke's Medical Center College of Medicine-William H. Quasha Memorial, Quezon City, Philippines; Philippine Society for Pediatric Radiology.
Department of Radiology, Seattle Children's Hospital, University of Washington School of Medicine, MA.7.220, 4800 Sand Point Way Northeast, Seattle, WA 98105, USA.
Radiol Clin North Am. 2020 May;58(3):569-582. doi: 10.1016/j.rcl.2019.12.006. Epub 2020 Feb 26.
Hematopoietic stem cell transplantation is an intravenous transfusion of pluripotent stem cells to repopulate the marrow and restore immunocompetence. However, before transplantation, the patient undergoes a conditioning regimen to eradicate the underlying disease, subsequently resulting in an immunocompromised state. Serious and some life-threatening complications involving any organ can occur. Currently, with advances in hematopoietic stem cell transplantation techniques and posttransplant management, more pediatric patients are now living longer and into their adulthood. The goal of this review article is to discuss the common neurologic, pulmonary, and abdominal complications associated with hematopoietic stem cell transplantation with emphasis on their imaging characteristics.
造血干细胞移植是一种通过静脉输注多能干细胞来重新填充骨髓并恢复免疫能力的治疗方法。然而,在移植前,患者需要接受预处理方案以根除潜在疾病,随后会导致免疫功能低下状态。可能会出现涉及任何器官的严重甚至危及生命的并发症。目前,随着造血干细胞移植技术和移植后管理的进步,越来越多的儿科患者存活时间更长并步入成年期。这篇综述文章的目的是讨论与造血干细胞移植相关的常见神经、肺部和腹部并发症,并重点介绍其影像学特征。