Biochemistry and Molecular Biology, Dasman Diabetes Institute, Kuwait City, Kuwait.
Pharmacology and Therapeutics Department, Faculty of Pharmacy, Kuwait University, Kuwait City, Kuwait.
Sci Rep. 2020 Apr 10;10(1):6170. doi: 10.1038/s41598-020-63149-7.
Myeloperoxidase (MPO) is positively associated with obesity and diet-induced insulin resistance. Angiopoietin-like protein 6 (ANGPTL6) regulates metabolic processes and counteract obesity through increased energy expenditure. This study aims to evaluate the plasma MPO and ANGPTL6 levels in obese and diabetic individuals as well as MPO association with biochemical markers of obesity. A total of 238 participants were enrolled, including 137 control and 101 type 2 diabetes (T2D) patients. ANGPTL6 and MPO levels and other biomarkers were measured via ELISA. ANGPTL6 levels were significantly higher in the diabetic population and obese individuals. When the group was stratified based on T2D, ANGPTL6 levels were significantly higher in obese-diabetic participants compared with non-obese-diabetics, but obese-non-diabetic individuals had similar ANGPTL6 levels to their controls. MPO levels were higher in obese compared with non-obese participants but did not differ between T2D and control participants. MPO levels were upregulated in obese compared with non-obese in both diabetics and non-diabetics. MPO was positively associated with ANGPTL6, triglyceride, BMI, TNF-alpha, high-sensitivity C-reactive protein, interleukin-6, and plasminogen activator inhibitor-1. Taken together, our findings suggest that both MPO and ANGPTL6 may regulate obesity, although MPO exerts this effect independent of diabetes while ANGPTL6 may have a modulatory role in diabetes.
髓过氧化物酶 (MPO) 与肥胖和饮食诱导的胰岛素抵抗呈正相关。血管生成素样蛋白 6 (ANGPTL6) 通过增加能量消耗来调节代谢过程并对抗肥胖。本研究旨在评估肥胖和糖尿病个体的血浆 MPO 和 ANGPTL6 水平，以及 MPO 与肥胖生化标志物的相关性。共纳入 238 名参与者，包括 137 名对照组和 101 名 2 型糖尿病 (T2D) 患者。通过 ELISA 测量 ANGPTL6 和 MPO 水平和其他生物标志物。糖尿病患者和肥胖个体的 ANGPTL6 水平明显升高。当根据 T2D 对该组进行分层时，与非肥胖型糖尿病患者相比，肥胖型糖尿病患者的 ANGPTL6 水平明显更高，但肥胖型非糖尿病患者的 ANGPTL6 水平与对照组相似。与非肥胖参与者相比，肥胖参与者的 MPO 水平更高，但 T2D 参与者和对照组参与者的 MPO 水平没有差异。在糖尿病患者和非糖尿病患者中，与非肥胖者相比，肥胖者的 MPO 水平均升高。MPO 与 ANGPTL6、甘油三酯、BMI、TNF-α、高敏 C 反应蛋白、白细胞介素 6 和纤溶酶原激活物抑制剂 1 呈正相关。综上所述，我们的研究结果表明，MPO 和 ANGPTL6 可能都参与了肥胖的调节，尽管 MPO 发挥这种作用不依赖于糖尿病，而 ANGPTL6 可能在糖尿病中具有调节作用。
