使用二甲基卤鎓盐进行傅-克型甲基化反应。
Friedel-Crafts Type Methylation with Dimethylhalonium Salts.
作者信息
Hämmerling Sebastian, Voßnacker Patrick, Steinhauer Simon, Beckers Helmut, Riedel Sebastian
机构信息
Institut für Chemie und Biochemie, Freie Universität Berlin, Fabeckstr.34/36, 14195, Berlin, Germany.
出版信息
Chemistry. 2020 Nov 11;26(63):14377-14384. doi: 10.1002/chem.202001457. Epub 2020 Oct 5.
The dimethylchloronium salt [Me Cl][Al(OTeF ) ] is used to methylate electron-deficient aromatic systems in Friedel-Crafts type reactions as shown by the synthesis of N-methylated cations, such as [MeNC F ] , [MeNC F I] , and [MeN C F ] . To gain a better understanding of such fundamental Friedel-Crafts reactions, the role of the dimethylchloronium cation has been evaluated by quantum-chemical calculations.
二甲基氯鎓盐[Me Cl][Al(OTeF ) ]用于在傅里德-克拉夫茨型反应中使缺电子芳香体系甲基化，如N-甲基化阳离子[MeNC F ] 、[MeNC F I] 和[MeN C F ] 的合成所示。为了更好地理解此类基本的傅里德-克拉夫茨反应，已通过量子化学计算评估了二甲基氯鎓阳离子的作用。
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