Department of Obstetrics and Gynecology, Wolfson Medical Center, Holon, Israel.
Fetal Neurology Clinic-Ultrasound in ObGyn Unit, Wolfson Medical Center, Holon, Israel.
Prenat Diagn. 2020 Jul;40(8):931-941. doi: 10.1002/pd.5704. Epub 2020 May 6.
The purpose of this study was to establish prognostic factors in fetuses diagnosed with periventricular pseudocysts (PVPCs) without known congenital infection, between 28 and 37 weeks of gestation.
This retrospective study included cases of fetal PVPC from 2008 to 2018. PVPCs were classified according to location, number, extension, morphology, and size. Additional findings, MRI and genetic studies were recorded. Pregnancy outcome, postnatal, or postmortem results were obtained. Images from patients with normal (Group 1) and abnormal postnatal development (Group 2) were compared for analysis of factors predictive of outcome.
One-hundred and fifteen pseudocysts were observed in 59 patients. In 34 fetuses (57%), the PVPC was an isolated finding. Thirty-nine patients delivered live newborns, 27% opted for termination of pregnancy, and 4 patients were lost to follow-up. Eighty-four percent of the liveborns had normal development. When assessing for the influence of pseudocyst characteristics, a wide CSP, or large head circumference, neither of these affected the outcome. The presence of additional anomalies was the only positive predictor for abnormal development regradless of specific PVPC characteristics (P = .002).
In fetuses with PVPCs, the presence of additional anomalies was the only predictor for adverse postnatal outcome. No association between cystic characteristics and adverse outcome was observed.
本研究旨在确定 28 至 37 孕周、无已知先天性感染的胎儿患有脑室周围假囊肿（PVPC）的预后因素。
本回顾性研究纳入了 2008 年至 2018 年的胎儿 PVPC 病例。根据位置、数量、延伸、形态和大小对 PVPC 进行分类。记录了其他发现、MRI 和遗传研究。获得了妊娠结局、产后或死后结果。对正常（第 1 组）和异常产后发育（第 2 组）患者的图像进行比较，以分析预测结局的因素。
59 例患者中有 115 个假囊肿。34 例胎儿（57%）的 PVPC 为孤立性发现。39 例分娩出活产新生儿，27%选择终止妊娠，4 例失访。84%的活产儿发育正常。在评估假囊肿特征的影响时，广泛的 CSP 或大头围均未影响结局。无论特定的 PVPC 特征如何，存在其他异常是唯一的不良预后预测因子（P=0.002）。
在患有 PVPC 的胎儿中，存在其他异常是不良产后结局的唯一预测因子。未观察到囊性特征与不良结局之间存在关联。
