School of Chemical Science and Engineering, Tongji University, Siping Road 1239, Shanghai, 200092, China.
School of Chemical Science and Engineering, Tongji University, Siping Road 1239, Shanghai, 200092, China; School of Materials Science and Engineering, Liaocheng University, Liaocheng, 252059, China.
Talanta. 2020 Jul 1;214:120856. doi: 10.1016/j.talanta.2020.120856. Epub 2020 Feb 24.
A luminescent metal-organic framework Eu functionalized Hf-MOF (Eu@1) is designed through post-synthesis modification (PSM) and utilized as a probe for detecting p-nitrophenol (PNP, the urinary metabolite of parathion, methyl-parathion and EPN) and 3-methyl-4-nitrophenol (PNMC, the urinary metabolite of fenitrothion). The apparent quenching effect in urine is observed from the Eu@1 with the addition of organophosphorus metabolites. The fluorescent probe has several appealing merits, such as high selectivity, excellent sensitivity (0.36 μg mL for PNP, 0.41 μg mL for PNMC), fast response time (less than 1 min) and easy preparation. Linear correlation between the fluorescence intensity of Eu@1 and the concentration of PNP and PNMC are from 0.005 to 0.15 mg mL and 0.005-0.30 mg mL, respectively. Furthermore, this fluorescent material also demonstrated the possibility for recycling. It is a prominent candidate for potential application in personalized monitoring the internal dose of human exposure to some organophosphorus pesticides.
通过后合成修饰（PSM）设计了一种发光金属-有机框架 Eu 功能化 Hf-MOF（Eu@1），并将其用作检测对硝基苯酚（PNP，对硫磷、甲基对硫磷和 EPN 的尿代谢物）和 3-甲基-4-硝基苯酚（PNMC，fenitrothion 的尿代谢物）的探针。在加入有机磷代谢物后，Eu@1 表现出明显的猝灭效应。荧光探针具有高选择性、优异的灵敏度（PNP 为 0.36μgmL，PNMC 为 0.41μgmL）、快速响应时间（小于 1 分钟）和易于制备等优点。Eu@1 的荧光强度与 PNP 和 PNMC 的浓度之间存在线性关系，范围分别为 0.005 至 0.15mgmL 和 0.005 至 0.30mgmL。此外，这种荧光材料还表现出了回收利用的可能性。它是一种很有前途的候选材料，可用于潜在应用于人体暴露于某些有机磷农药的内部剂量的个性化监测。
