Department of Head and Neck Surgery, Kaiser Permanente Oakland Medical Center, 3600 Broadway, Suite 40, Oakland, CA 94611, USA.
Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, 601 North Caroline Street, 6th Floor, Baltimore, MD 21287, USA.
Immunol Allergy Clin North Am. 2020 May;40(2):233-249. doi: 10.1016/j.iac.2019.12.003. Epub 2020 Jan 18.
Refractory rhinosinusitis can be related to comorbid medical conditions, including primary immunodeficiency. Given the prevalence of immunodeficiency, clinicians should have a low threshold to consider these diagnoses. This article reviews primary immunodeficiencies contributing to chronic rhinosinusitis, including a proposed diagnostic work-up and the evidence for treatment in this unique population.
难治性鼻窦炎可能与合并症有关，包括原发性免疫缺陷。鉴于免疫缺陷的普遍性，临床医生应降低门槛，考虑这些诊断。本文回顾了导致慢性鼻窦炎的原发性免疫缺陷，包括提出的诊断性检查以及在这一特殊人群中治疗的证据。
