Dobozy O, Brindak O, Csaba G
Department of Biology, Semmelweis University of Medicine, Budapest, Hungary.
Acta Physiol Hung. 1988;72(2):159-63.
One day after the cessation of treatment the Leydig cells of the fetuses of pregnant rats, treated between the 11th and 15th or the 16th and 20th days of gestation, reacted to pituitary hormones. This finding indicates that both the receptors and the postreceptor mechanisms were in operative state. The effect of the thyrotropic hormone (TSH) overlaps the effect of related gonadotropic hormone (hCG), although this effect becomes smaller from the 21st day. The parameters investigated - the spectrocyto-fluorimetrically measured RNA-DNA ratio and the plasma testosterone level - ran generally in parallel. Similarly to the above-mentioned hormones, prolactin also increased the testosterone level (though to lesser degree than hCG and TSH did), however, while it increased the RNA level but at the age of 16 days, it decreased it the age of 21 days. Somatotropin (GH) also increased somewhat the testosterone level; however, the effects of the two related hormones (Pr and GH) fell far beyond the effect of either TSH or hCG.
在妊娠第11至15天或第16至20天接受治疗的怀孕大鼠胎儿，在停止治疗一天后，其睾丸间质细胞对垂体激素产生了反应。这一发现表明受体和受体后机制均处于运作状态。促甲状腺激素（TSH）的作用与相关促性腺激素（hCG）的作用重叠，尽管从第21天起这种作用会变小。所研究的参数——通过光谱细胞荧光法测量的RNA-DNA比率和血浆睾酮水平——总体上呈平行变化。与上述激素类似，催乳素也提高了睾酮水平（尽管程度低于hCG和TSH），然而，它在16日龄时提高了RNA水平，但在21日龄时却降低了RNA水平。生长激素（GH）也使睾酮水平有所升高；然而，这两种相关激素（Pr和GH）的作用远远低于TSH或hCG的作用。
