Fazekas T, Szekeres L
First Department of Medicine, University Medical School, Szeged, Hungary.
Acta Physiol Hung. 1988;72(2):191-9.
The cardiac effects of the phospholipase A2 inhibiting agent chloroquine were studied in dogs, rats and cats. During left anterior descending coronary artery occlusion produced in anaesthetized mongrel dog, chloroquine pretreatment considerably reduced the epicardial ST-segment elevation in the ischaemic area, as well as the number of premature ventricular contractions. In conscious male Sprague-Dawley CFY rats it diminished the duration and prolonged the latency of appearance of the early post-infarction arrhythmias and increased the survival rate following coronary artery ligation. Chloroquine failed to affect the ventricular fibrillation threshold in the normoxic cat heart. The cardioprotective action of chloroquine could be explained at least partly by its antiphospholipase activity.
研究了磷脂酶A2抑制剂氯喹对犬、大鼠和猫的心脏作用。在麻醉杂种犬造成左前降支冠状动脉闭塞期间，氯喹预处理可显著降低缺血区的心外膜ST段抬高以及室性早搏的数量。在清醒雄性斯普拉格-道利CFY大鼠中，它缩短了心肌梗死后早期心律失常的持续时间，延长了其出现的潜伏期，并提高了冠状动脉结扎后的存活率。氯喹对常氧猫心脏的室颤阈值没有影响。氯喹的心脏保护作用至少部分可由其抗磷脂酶活性来解释。
