• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

与月经期相比，排卵期女性血小板对二磷酸腺苷（ADP）的钙反应增强：采用fura-2技术测量细胞质钙。

Increased calcium response to ADP in blood platelets from women during ovulation compared with menstruation: cytoplasmic calcium measured with the fura-2 technique.

作者信息

Pedersen O S, Reichelt K L

机构信息

Department of Paediatric Research, Rikshospitalet, Norway.

出版信息

Acta Physiol Scand. 1988 Mar;132(3):335-9. doi: 10.1111/j.1748-1716.1988.tb08337.x.

DOI:10.1111/j.1748-1716.1988.tb08337.x
PMID:3227879
Abstract

Blood platelets from women showed increased sensitivity to adenosine diphosphate (ADP) during ovulation compared with menstruation. The increased sensitivity was registered as an increase in cytoplasmic calcium response measured with the fluorescent indicator fura-2. Agonist dose-response studies revealed an increased maximal response, but the dose that gave half maximal response was unchanged. This indicates an increased mobility of calcium, without changed affinity to receptor(s).

摘要

与月经期间相比，女性的血小板在排卵期间对二磷酸腺苷（ADP）的敏感性增加。这种敏感性增加表现为用荧光指示剂fura-2测量的细胞质钙反应增加。激动剂剂量反应研究显示最大反应增加，但产生半数最大反应的剂量没有变化。这表明钙的流动性增加，而对受体的亲和力没有改变。

相似文献

1
Increased calcium response to ADP in blood platelets from women during ovulation compared with menstruation: cytoplasmic calcium measured with the fura-2 technique.与月经期相比，排卵期女性血小板对二磷酸腺苷（ADP）的钙反应增强：采用fura-2技术测量细胞质钙。
Acta Physiol Scand. 1988 Mar;132(3):335-9. doi: 10.1111/j.1748-1716.1988.tb08337.x.
2
Effect of epinephrine on rapid ADP-induced aggregation, protein phosphorylation, and cytoplasmic calcium dynamics of platelets: a quenched-flow study.肾上腺素对二磷酸腺苷快速诱导的血小板聚集、蛋白质磷酸化及细胞质钙动力学的影响：一项淬灭流动研究
J Lab Clin Med. 1988 Nov;112(5):603-11.
3
Desensitization of the platelet aggregation response to ADP: differential down-regulation of the P2Y1 and P2cyc receptors.血小板对ADP聚集反应的脱敏：P2Y1和P2cyc受体的差异性下调
Thromb Haemost. 2000 Sep;84(3):484-91.
4
Enhancement of ADP-induced aggregation by 5-HT in rabbit platelets.5-羟色胺对兔血小板中ADP诱导的聚集的增强作用。
Zhongguo Yao Li Xue Bao. 1998 Jan;19(1):58-62.
5
[A decrease in the stimulated level of free intracellular calcium in thrombocytes during refractoriness].
Biull Eksp Biol Med. 1988 Dec;106(12):672-4.
6
N-Ethylmaleimide induces disaggregation of platelets preaggregated by ADP and thrombin and decreases cytoplasmic calcium level.N-乙基马来酰亚胺可诱导由二磷酸腺苷（ADP）和凝血酶预聚集的血小板解聚，并降低细胞质钙水平。
Biochemistry (Mosc). 2000 Feb;65(2):230-6.
7
Ca+2 mobilization and fibrinogen binding of platelets refractory to adenosine diphosphate stimulation.对二磷酸腺苷刺激无反应的血小板的钙离子动员和纤维蛋白原结合
J Lab Clin Med. 1985 Aug;106(2):111-22.
8
ADP-mimicking platelet aggregation caused by rugosin E, an ellagitannin isolated from Rosa rugosa Thunb.由从玫瑰（Rosa rugosa Thunb.）中分离出的鞣花单宁rugosin E引起的ADP模拟血小板聚集。
Thromb Haemost. 1997 Mar;77(3):555-61.
9
[Free cytoplasmic calcium and thrombocyte aggregation in patients with ischemic heart disease. The effect of ADP, thrombocyte activation factor and serotonin].[缺血性心脏病患者的游离细胞质钙与血小板聚集。ADP、血小板激活因子和5-羟色胺的作用]
Biull Vsesoiuznogo Kardiol Nauchn Tsentra AMN SSSR. 1986;9(2):90-6.
10
Enhanced increases in cytosolic Ca2+ in ADP-stimulated platelets from patients with delta-storage pool deficiency--a possible indicator of interactions between granule-bound ADP and the membrane ADP receptor.δ-储存池缺乏症患者的ADP刺激血小板中胞质Ca2+增强增加——颗粒结合ADP与膜ADP受体之间相互作用的一个可能指标。
Thromb Haemost. 1997 Feb;77(2):376-82.

引用本文的文献

1
Guinea-pig megakaryocytes can respond to external ADP by activating Ca2(+)-dependent potassium conductance.豚鼠巨核细胞可通过激活钙依赖性钾电导对外部二磷酸腺苷作出反应。
J Physiol. 1990 Dec;431:207-24. doi: 10.1113/jphysiol.1990.sp018327.