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左心室辅助装置合并机械心脏瓣膜患者的病例系列。

A case series of patients with left ventricular assist devices and concomitant mechanical heart valves.

机构信息

Department of Internal Medicine, University of Illinois at Chicago/Advocate Christ Medical Center, Oak Lawn, IL, USA.

Department of Cardiology, Advocate Christ Medical Center, Oak Lawn, IL, USA.

出版信息

Artif Organs. 2020 Oct;44(10):1050-1054. doi: 10.1111/aor.13702. Epub 2020 Apr 23.

DOI:10.1111/aor.13702
PMID:32279355
Abstract

Mechanical heart valves left in situ at the time of left ventricular assist device (LVAD) implantation are thought to potentially increase the risk of thromboembolism. Recommendations exist to replace dysfunctional mechanical mitral valves and any mechanical aortic valves at the time of LVAD implantation. Due to potential increases in cardiopulmonary bypass time and associated comorbidities with valve replacement, leaving a functional mechanical valve in place at LVAD implantation has been suggested to be a safe option. We retrospectively reviewed all patients with prior mechanical mitral or aortic valves undergoing LVAD implantation at our center between 2012 and 2017. Echocardiograms were read by a single cardiologist to assess for mechanical valve dysfunction. We identified 15 patients. Five patients had major bleeding requiring transfusion. On follow-up, 2 patients had hemorrhagic stroke and 2 had transient ischemic attach/ischemic stroke. In addition, 2 patients had LVAD thrombosis and 2 patients had LVAD driveline malfunction. Mild mechanical valve regurgitation was identified on follow-up echocardiograms of 2 patients. Rate of complications in patients with mechanical valves undergoing LVAD implantation was comparable to that reported for the general LVAD population. Leaving a functional mechanical valve in place at the time of LVAD implantation could be a reasonable alternative to valve replacement. More data are required to further guide patient care in these individuals.

摘要

在植入左心室辅助装置 (LVAD) 时,遗留原位的机械心脏瓣膜被认为可能会增加血栓栓塞的风险。建议在植入 LVAD 时更换功能失调的机械二尖瓣和任何机械主动脉瓣。由于更换瓣膜可能会增加心肺转流时间,并伴有相关的合并症,因此建议在植入 LVAD 时保留功能正常的机械瓣膜是一种安全的选择。我们回顾性分析了 2012 年至 2017 年间在我们中心接受 LVAD 植入的所有既往存在机械二尖瓣或主动脉瓣的患者。由一名心脏病专家对超声心动图进行解读,以评估机械瓣膜功能障碍。我们共确定了 15 名患者。其中 5 名患者发生大出血需要输血。在随访中,2 名患者发生出血性卒中和 2 名患者发生短暂性脑缺血发作/缺血性卒中。此外,2 名患者出现 LVAD 血栓形成和 2 名患者出现 LVAD 驱动线故障。在 2 名患者的后续超声心动图中发现有轻度机械瓣膜反流。在植入机械瓣膜的 LVAD 患者中,并发症的发生率与一般 LVAD 人群相似。在植入 LVAD 时保留功能正常的机械瓣膜可能是瓣膜置换的合理替代方案。需要更多的数据来进一步指导这些患者的治疗。

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