Department of Chemistry, Indian Institute of Technology (Indian School of Mines), Dhanbad, Jharkhand 826 004, INDIA.
Department of Chemistry, Indian Institute of Technology (Indian School of Mines), Dhanbad, Jharkhand 826 004, INDIA.
Mater Sci Eng C Mater Biol Appl. 2020 Jun;111:110777. doi: 10.1016/j.msec.2020.110777. Epub 2020 Feb 25.
Herein, we have developed a photocatalytic, fluorescent bismuth phosphate@graphene oxide (BiPO@GO) based magnetic nano-sized-molecularly imprinted polymer (MMIP) for detection, removal, and degradation of ciprofloxacin (CIP) via atom transfer radical polymerization (ATRP) process. CIP is a very popular antibiotic, but their heavy doses in recent time, made them an environmental threat. The imprinted polymer was synthesized using N-vinyl caprolactam, N, N-methylene bis-acrylamide, ZnFeO nanoparticle, and Bi(PO)@GO as a biocompatible monomer, crosslinker, magnetic moiety, and photocatalyst, respectively. The characterization of the molecularly imprinted polymer was systematically evaluated by electrochemical techniques, X-ray diffraction, fluorescence spectroscopy, scanning electron microscopy, etc. The prepared BiPO@GO modified CIP-imprinted magnetic polymer (BiPO@GO-MMIPs) shows high selectivity towards their template/target analyte (i.e., CIP) and used for their visual (via fluorescence study) and trace level detection (via the electrochemical study) in various kind of complex matrix. The dual behaviour i.e. electrochemical and optical sensing of CIP was successfully achieved in a good linear range of 39.0 to 740.0 μg L with detection of limit (LOD) of 0.39 μg L for electrochemical study and 39.0 to 328.0 μg L and LOD of 0.40 μg L for optical study. The prepared BiPO@GO-MMIPs were successfully used for the detection of CIP from complex matrix like blood serum, whole blood, and milk sample as well as removal and degradation of CIP with good efficiency.
在此，我们通过原子转移自由基聚合（ATRP）过程，开发了一种基于光催化、荧光的磷酸铋@氧化石墨烯（BiPO@GO）基磁性纳米尺寸分子印迹聚合物（MMIP），用于检测、去除和降解环丙沙星（CIP）。CIP 是一种非常流行的抗生素，但最近它们的大量使用对环境构成了威胁。印迹聚合物是使用 N-乙烯基己内酰胺、N，N-亚甲基双丙烯酰胺、ZnFeO 纳米粒子和 Bi(PO)@GO 作为生物相容单体、交联剂、磁性部分和光催化剂分别合成的。通过电化学技术、X 射线衍射、荧光光谱、扫描电子显微镜等对印迹聚合物进行了系统的表征。制备的 BiPO@GO 修饰的 CIP 印迹磁性聚合物（BiPO@GO-MMIPs）对其模板/目标分析物（即 CIP）表现出高选择性，并用于其在各种复杂基质中的可视化（通过荧光研究）和痕量检测（通过电化学研究）。成功实现了 CIP 的电化学和光学双重传感行为，在 39.0 至 740.0μg L 的良好线性范围内，电化学研究的检测限（LOD）为 0.39μg L，光学研究的检测限（LOD）为 39.0 至 328.0μg L 和 0.40μg L。成功地将制备的 BiPO@GO-MMIPs 用于从血清、全血和牛奶等复杂基质中检测 CIP，以及以高效率去除和降解 CIP。
