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肠内营养:成人活动性克罗恩病的最佳护理途径

Exclusive enteral nutrition: An optimal care pathway for use in adult patients with active Crohn's disease.

作者信息

Day Alice, Wood Jessica, Melton Sarah, Bryant Robert V

机构信息

Department of Gastroenterology, The Queen Elizabeth Hospital Adelaide South Australia Australia.

Department Nutrition and Dietetics, The Alfred Melbourne Victoria Australia.

出版信息

JGH Open. 2019 Sep 10;4(2):260-266. doi: 10.1002/jgh3.12256. eCollection 2020 Apr.

Abstract

BACKGROUND AND AIM

Exclusive enteral nutrition (EEN) is progressively being used as a therapeutic option for adults with Crohn's Disease (CD); however, there is no standardized approach to delivering this therapy. The aim of this study is to develop an optimal care pathway for using EEN in adults with CD. This will create a standard of care that can be used as a benchmark practice and will provide direction for future research.

METHODS

A working group of 12 multidisciplinary inflammatory bowel disease specialists across Australia and New Zealand was convened to develop a practical, clinically focused care pathway for using EEN in adults with active CD. Six key areas were identified as part of the care pathway: clinical indications, nutrition assessment, EEN protocol, monitoring, accessing formula, and food reintroduction. Current literature was identified via systematic review, and quality of evidence was graded. Consensus expert opinion was used where literature gaps were identified.

RESULTS

An optimal care pathway for using EEN in adults with CD was developed with six key consensus statements on how to use EEN in adults with active CD. These key statements identify clinical indications for use, nutrition assessment, enteral prescription and duration of therapy, monitoring criteria, food reintroduction, and the role of partial EEN. An accompanying patient resource was also developed.

CONCLUSION

EEN is recommended as a treatment option to induce remission in adults with active CD. The consensus statements developed are practical and are based on best available evidence and expert opinion to assist in developing a standardized approach to delivering EEN therapy.

摘要

背景与目的

全肠内营养(EEN)正逐渐被用作成人克罗恩病(CD)的一种治疗选择;然而,实施这种治疗尚无标准化方法。本研究的目的是制定成人CD患者使用EEN的最佳护理路径。这将创建一种可作为基准实践的护理标准,并为未来研究提供方向。

方法

召集了一个由澳大利亚和新西兰12名多学科炎症性肠病专家组成的工作小组,以制定针对成人活动性CD患者使用EEN的实用、以临床为重点的护理路径。护理路径的六个关键领域被确定为:临床指征、营养评估、EEN方案、监测、获取配方食品以及食物重新引入。通过系统综述确定当前文献,并对证据质量进行分级。在发现文献空白的地方采用专家共识意见。

结果

制定了成人CD患者使用EEN的最佳护理路径,其中包含关于成人活动性CD患者如何使用EEN的六项关键共识声明。这些关键声明确定了使用的临床指征、营养评估、肠内处方和治疗持续时间、监测标准、食物重新引入以及部分EEN的作用。还开发了一份配套的患者资源。

结论

推荐EEN作为诱导成人活动性CD缓解的一种治疗选择。制定的共识声明实用且基于现有最佳证据和专家意见,有助于制定实施EEN治疗的标准化方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbc9/7144766/919f3ad680fb/JGH3-4-260-g001.jpg

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