Tsuchiya Atsunori, Tanaka Tomoyuki, Shibasaki Yasuhiko, Terai Shuji
Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences Niigata University Niigata Japan.
Department of Hematology, Endocrinology and Metabolism, Faculty of Medicine Niigata University Niigata Japan.
JGH Open. 2019 Sep 6;4(2):312-314. doi: 10.1002/jgh3.12253. eCollection 2020 Apr.
A 61-year-old woman with hypereosinophilia and elevated interleukin (IL)-5 level was admitted to our hospital after detection of multiple liver tumors. Liver biopsy demonstrated that the tumor consisted of scar tissue with remnants of eosinophilic infiltration, suggesting that it had formed by massive eosinophilic infiltration. The hypereosinophilia was treated mainly by prednisolone, and thereafter, the liver tumors disappeared. However, 10 months postadmission, CD4+ T-cell lymphoma, which can produce IL-5, was detected in the nasopharynx and oropharynx. Therefore, we believe that this is a rare case of hypereosinophilia-related liver pseudotumor induced by presumed by IL-5 elevation.
一名61岁女性，伴有嗜酸性粒细胞增多症且白细胞介素（IL）-5水平升高，在检测出多发肝肿瘤后入住我院。肝脏活检显示肿瘤由伴有嗜酸性粒细胞浸润残余的瘢痕组织构成，提示其由大量嗜酸性粒细胞浸润形成。嗜酸性粒细胞增多症主要通过泼尼松龙治疗，此后肝肿瘤消失。然而，入院10个月后，在鼻咽部和口咽部检测到可产生IL-5的CD4 + T细胞淋巴瘤。因此，我们认为这是一例罕见的由推测的IL-5升高引起的嗜酸性粒细胞增多症相关肝假性肿瘤病例。
