从癌症干细胞模型的角度看两种处于临床试验阶段的癌症干细胞靶向疗法。
Two cancer stem cell-targeted therapies in clinical trials as viewed from the standpoint of the cancer stem cell model.
机构信息
California Institute for Regenerative Medicine, Oakland, California, USA.
出版信息
Stem Cells Transl Med. 2020 Aug;9(8):821-826. doi: 10.1002/sctm.19-0424. Epub 2020 Apr 12.
Abstract
A key implication of the cancer stem cell model is that for a cancer therapy to be curative, it is imperative to eliminate the cancer stem cells (CSCs) that drive tumor progression. The California Institute for Regenerative Medicine is supporting two novel approaches that target CSCs, one an antibody-mediated immunotherapy targeting CD47 and the other an antibody targeting ROR1. This article summarizes the evidence that CSCs are targeted and discusses the results of early clinical trials within the context of the CSC model.
摘要
癌症干细胞模型的一个重要含义是，为了使癌症治疗具有根治性，消除驱动肿瘤进展的癌症干细胞（CSC）是至关重要的。加利福尼亚再生医学研究所正在支持两种针对 CSC 的新方法，一种是针对 CD47 的抗体介导的免疫疗法，另一种是针对 ROR1 的抗体。本文总结了针对 CSC 的证据，并在 CSC 模型的背景下讨论了早期临床试验的结果。
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