Natural Products Research Unit, Center of Excellence for Innovation in Chemistry, Department of Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen, Thailand.
Department of Biochemistry, Faculty of Science, Khon Kaen University, Khon Kaen, Thailand.
Nat Prod Res. 2021 Dec;35(23):4922-4929. doi: 10.1080/14786419.2020.1749610. Epub 2020 Apr 13.
A new (naphthalenyl)methyl acetate, (1,4,5-trimethoxynaphthalen-2-yl)methyl acetate () and ()-4,5-dihydroxy-2-methyltetralone () were isolated together with five lupane triterpenes (), naphthoquinone derivatives (-), coumarins ( and ) and a vanillic acid () from the stems of Their structures were established through spectroscopic analysis, IR, 1D and 2D NMR. Both and displayed significant cytotoxicity against three cancer cell lines including HeLa, HCT116 and MCF-7, with IC values in the range of 5.05-15.90 µg/mL, while exhibited moderate cytotoxicity against HeLa and HCT116 cell lines and was not toxic to Vero cells.
从 的茎中分离得到了一个新的（萘基）甲基乙酸酯（1,4,5-三甲氧基萘-2-基）甲基乙酸酯（）和（）-4,5-二羟基-2-甲基四氢酮（），以及五种羽扇豆烷三萜（）、萘醌衍生物（-）、香豆素（和）和香草酸（）。通过光谱分析、IR、1D 和 2D NMR 确定了它们的结构。和都显示出对三种癌细胞系（包括 HeLa、HCT116 和 MCF-7）的显著细胞毒性，IC 值在 5.05-15.90 μ g/mL 范围内，而对 HeLa 和 HCT116 细胞系表现出中等细胞毒性，对 Vero 细胞没有毒性。
