Wang Anqi, Duan Leizhen, Huang Hui, Ma Jun, Zhang Yawei, Ma Qiang, Guo Yao, Li Zhiyuan, Cheng Xuemin, Zhu Jingyuan, Zhou Guoyu, Ba Yue
Department of Environment Health, School of Public Health, Zhengzhou University, Zhengzhou, Henan, P. R. China.
Environment and Health Innovation Team, School of Public Health, Zhengzhou University, Zhengzhou, Henan, P. R. China.
Int J Environ Health Res. 2022 Jan;32(1):232-241. doi: 10.1080/09603123.2020.1747601. Epub 2020 Apr 13.
To assess the association between fluoride exposure and children's behavioural outcomes, we recruited 325 resident school-age children (7-13 years old) lived in Tongxu County of Henan Province in China. We measured urinary fluoride (UF) concentrations using the ion-selective electrode method. Children's behavioural outcomes were assessed by Conners' Parent Rating Scale-Revised, including conduct problems, learning problems, psychosomatic problems, impulsive-hyperactive, anxiety, and ADHD index. It turned out that each 1.0 mg/L increment in UF concentration corresponded with an elevation in the psychosomatic problem score of 4.01 (95% : 2.74, 5.28) and a 97% (= 1.97, 95% : 1.19, 3.27) increase in the prevalence of psychosomatic problems after adjusting for potential influencing factors. The sensitivity analysis results were consistent with those observed in our preliminary analysis. Our study suggests that fluoride exposure is positively related to the behavioural problem in school-age children, psychosomatic problem in particular.
为评估氟暴露与儿童行为结果之间的关联，我们招募了325名居住在中国河南省通许县的学龄儿童（7至13岁）。我们使用离子选择电极法测量尿氟（UF）浓度。儿童的行为结果通过康纳斯父母评定量表修订版进行评估，包括品行问题、学习问题、身心问题、冲动多动、焦虑和注意力缺陷多动障碍指数。结果显示，在调整潜在影响因素后，UF浓度每增加1.0mg/L，身心问题得分升高4.01（95%可信区间：2.74，5.28），身心问题患病率增加97%（=1.97，95%可信区间：1.19，3.27）。敏感性分析结果与我们初步分析中观察到的结果一致。我们的研究表明，氟暴露与学龄儿童的行为问题呈正相关，尤其是身心问题。
